A more clinically relevant model of ventilator-associated pneumonia?
A more clinically relevant model of ventilator-associated pneumonia?
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呼吸机相关性肺炎更具临床相关性的模型？
DOI：
10.1097/aln.0000000000000223
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发表时间：
2014
期刊：
影响因子：
8.8
通讯作者：
Pittet,Jean-Francois
中科院分区：
文献类型：
--
作者：
Wagener,BrantM;Pittet,Jean-Francois
Ventilator-associated pneumonia (VAP) is defined as a nosocomial lung infection that develops at least five days after endotracheal intubation and is associated with significant mortality and morbidity in intensive care unit patients1. While a variety of microorganisms can be the causative agent in VAP, the most notable is Pseudomonas aeruginosa. Several animal models of VAP have been published in order to understand the mechanisms and clinical course of VAP in humans2–4. However, none of them has reproduced the most prevalent human etiology or the primary pathogenic mechanism of the disease, ie aspiration of oropharyngeal pathogens. In this issue of the Journal, Bassi et al. propose a novel experimental model of VAP in pigs that is induced via an oropharyngeal challenge of Pseudomonas aeruginosa that may help to better understand the pathogenesis of VAP and possible therapeutic approaches to prevent and/or treat it in humans5.Recent clinical studies report an incidence from two to sixteen episodes per 1,000 ventilatordays and an attributable mortality of 3–17%. Furthermore, not only is VAP a major cause of morbidity, longer stays in the intensive care unit and longer duration of mechanical ventilation, but there are additional hospital costs of up to $40,000 per episode1. Timely, adequate and accurate administration of antibiotics is predictive of hospital survival; and alternate routes of administration, including aerosolized antibiotics, are being studied to augment treatment effect while diminishing unwanted side effects4, 6, 7. Finally, it is clear that preventive strategies such as nurse-administered oral hygiene and “ventilator bundles” lower the rate of acquiring VAP6. Given the above, finding a clinically relevant experimental model that closely reflects the human pathogenesis of VAP is paramount to understanding what can be done to further prevent its occurrence and make treatment protocols more efficacious.
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DOI：
--
发表时间：
1974
期刊：
影响因子：
--
作者：
E. Haus;F. Halberg;M. Loken;Y. Kim
通讯作者：
Y. Kim
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DOI：
--
发表时间：
1970
期刊：
Strahlentherapie
影响因子：
--
作者：
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通讯作者：
D. Rotkovská
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DOI：
--
发表时间：
1976
期刊：
International Journal of Radiation Oncology, Biology, Physics
影响因子：
--
作者：
H. Barbason
通讯作者：
H. Barbason
造血细胞对小鼠全身照射敏感性的昼夜节律性。
DOI：
--
发表时间：
1968
期刊：
International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine
影响因子：
--
作者：
Y. Ueno
通讯作者：
Y. Ueno
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影响因子：
3.4
作者：
S. Gibbs;G. Casarett
通讯作者：
G. Casarett