The inverted "U-shaped" dose-effect relationships in learning and memory: Modulation of arousal and consolidation
The inverted "U-shaped" dose-effect relationships in learning and memory: Modulation of arousal and consolidation
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DOI：
10.2201/nonlin.003.01.002
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Bucherelli, Corrado
中科院分区：
文献类型：
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作者：
Baldi, Elisabetta;Bucherelli, Corrado
在生物非线性关系的丰富领域中，也存在倒U形剂量效应。关于认知功能，在几种动物种属的几种学习模式中，已广泛报告了许多活性化合物的这种现象，并且不依赖于给药途径（全身或脑内）或给药。石灰（训练前或训练后）。这篇评论总结了它最有趣的方面。的假设，机制支持它的报告和讨论，特别强调参与情绪唤醒水平的调制记忆过程。研究结果的充分记录，压力，情绪唤醒，外周肾上腺素水平，大脑去甲肾上腺素水平和记忆巩固之间的关系的报告。对这些进行了讨论，并强调了进一步研究的必要性。
In the ample field of biological non-linear relationships there is also the inverted U-shaped dosed effect. In relation to cognitive functions, this phenomenon has been widely reported for many ac-live compounds, in several learning paradigms, in several animal species and does not depend on either administration route (systemic or endocerebral) or administration. lime (before or after training). This review summarizes its most interesting aspects. The hypothesized, mechanisms supporting it are reported and discussed, with particular emphasis on the participation of emotional arousal levels in the modulation of memory processes. Findings on the well documented, relationship between stress, emotional arousal, peripheral epinephrine levels, cerebral norepinephrine levels and memory consolidation are reported. These are discussed and the need for further research is underlined.