Clinical implications of AEG-1 in liver metastasis of colorectal cancer
Clinical implications of AEG-1 in liver metastasis of colorectal cancer
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DOI：
10.1007/s12032-012-0186-z
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发表时间：
2012-12-01
期刊：
影响因子：
3.4
通讯作者：
Piao, Daxun
中科院分区：
文献类型：
--
作者：
Jiang, Tao;Zhu, Anlong;Piao, Daxun
本研究旨在探讨AEG-1在结直肠癌中的作用及其与结直肠癌病理特征和预后的关系。采用RT-PCR和免疫组化方法检测AEG-1 mRNA和蛋白在肝转移组和非肝转移组肿瘤细胞中的表达水平。分析AEG-1与结直肠癌临床病理参数的关系。AEG-1阳性表达218例（41.92%）。AEG-1在肝转移组的mRNA和蛋白水平均高于无肝转移组（P = 0.01）。AEG-1蛋白表达与患者年龄、杜克分期、远处转移有关（P值分别为0.001、0.001和0.016）。生存分析后，AEG-1蛋白高表达的病例的术后疾病特异性生存率显著低于无/低表达AEG-1蛋白的病例（P = 0.001）。在考克斯回归分析中，组织学分级、杜克分期和AEG-1是独立的预后因素（P值分别为0.035、0.001和0.010）。AEG-1蛋白可能成为结直肠癌早期肝转移的一个新的潜在生物标志物。
The aim of the study was to investigate the role of AEG-1 in colorectal cancer and the relationship between AEG-1 protein expression and pathological characteristics and prognosis in colorectal cancer. The AEG-1 mRNA and protein expression level between the tumor cells from the cases with liver metastasis and those from the ones without live metastasis were detected by RT-PCR and immunohistochemistry staining. The relationship between AEG-1 and clinicopathological parameters of colorectal cancer was determined. AEG-1 expressed positively in 218 (41.92%) of the 520 cases examined. It showed that both mRNA and protein level AEG-1 were over-expressed in the cases with liver metastasis compared with those without liver metastasis (P = 0.01). After immunohistochemistry analysis, the expression of AEG-1 protein was related to age, Duke's stage and distant metastasis (P = 0.001, 0.001 and 0.016, respectively). After survival analysis, the cases with highly expressed AEG-1 protein attained a significantly poorer postoperative disease-specific survival than those with none/low-expressed AEG-1 protein (P = 0.001). In the Cox regression test, histological grade, Duke's stage and AEG-1 were detected as the independent prognostic factors (P = 0.035, 0.001 and 0.010, respectively). AEG-1 protein may be a potential new early liver metastasis biomarker of colorectal cancer.