HIV-INFECTION IS ACTIVE AND PROGRESSIVE IN LYMPHOID-TISSUE DURING THE CLINICALLY LATENT STAGE OF DISEASE
HIV-INFECTION IS ACTIVE AND PROGRESSIVE IN LYMPHOID-TISSUE DURING THE CLINICALLY LATENT STAGE OF DISEASE
复制标题
DOI：
10.1038/362355a0
复制
发表时间：
1993-03-25
期刊：
影响因子：
64.8
通讯作者：
FAUCI, AS
中科院分区：
文献类型：
--
作者：
PANTALEO, G;GRAZIOSI, C;FAUCI, AS
人类免疫缺陷病毒 (HIV) 原发感染后通常会出现病毒血症，伴或不伴临床症状1-3。接下来是一段较长的临床潜伏期。在此期间，几乎没有可检测到的病毒血症，血液中受感染细胞的数量非常低，并且很难证明这些细胞中的病毒表达4。我们同时分析了处于艾滋病毒疾病不同阶段的同一个体的血液和淋巴器官中的病毒负荷和病毒复制水平。在这里，我们报告说，在早期疾病中，外周血与淋巴器官中的病毒负荷和病毒复制水平之间存在二分法。 HIV疾病在整个临床潜伏期的淋巴组织中都很活跃，即使在血液中病毒活性极低的时候也是如此。
PRIMARY infection with the human immunodeficiency virus (HIV) is generally followed by a burst of viraemia with or without clinical symptoms1-3. This in turn is followed by a prolonged period of clinical latency. During this period there is little, if any, detectable viraemia, the numbers of infected cells in the blood are very low, and it is extremely difficult to demonstrate virus expression in these cells4. We have analysed viral burden and levels of virus replication simultaneously in the blood and lymphoid organs of the same individuals at various stages of HIV disease. Here we report that in early-stage disease there is a dichotomy between the levels of viral burden and virus replication in peripheral blood versus lymphoid organs. HIV disease is active in the lymphoid tissue throughout the period of clinical latency, even at times when minimal viral activity is demonstrated in blood.