Sparse odor coding in awake behaving mice
Sparse odor coding in awake behaving mice
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DOI：
10.1523/jneurosci.0884-06.2006
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发表时间：
2006-08-23
影响因子：
5.3
通讯作者：
Gelperin, Alan
中科院分区：
文献类型：
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作者：
Rinberg, Dmitry;Koulakov, Alex;Gelperin, Alan
二尖瓣细胞的反应代表了嗅球第一阶段气味处理的结果。我们关于二尖瓣细胞活动的大部分知识是从麻醉动物的记录中获得的。我们比较了气味引起的清醒小鼠和麻醉小鼠二尖瓣细胞放电率的变化。我们发现气味引起的二尖瓣细胞放电率的变化在麻醉状态下比在清醒状态下更大，更频繁地观察到。只有27%的二尖瓣细胞在麻醉状态下对气味有反应，在清醒状态下也对气味有反应。与麻醉状态相比，清醒状态下的反应幅度较小，部分反应发生了符号变化。因此，在清醒状态下的小鼠嗅球中的气味表现比在麻醉状态下的小鼠要少。对造成这一现象的机制提出了定性的解释。
Responses of mitral cells represent the results of the first stage of odor processing in the olfactory bulb. Most of our knowledge about mitral cell activity has been obtained from recordings in anesthetized animals. We compared odor-elicited changes in firing rate of mitral cells in awake behaving mice and in anesthetized mice. We show that odor-elicited changes in mitral cell firing rate were larger and more frequently observed in the anesthetized than in the awake condition. Only 27% of mitral cells that showed a response to odors in the anesthetized state were also odor responsive in the awake state. The amplitude of their response in the awake state was smaller, and some of the responses changed sign compared with their responses in the anesthetized state. The odor representation in the olfactory bulb is therefore sparser in awake behaving mice than in anesthetized preparations. A qualitative explanation of the mechanism responsible for this phenomenon is proposed.