Ovarian cancer risk counseling: a guide for the practitioner.
Ovarian cancer risk counseling: a guide for the practitioner.
复制标题
卵巢癌风险咨询：从业者指南。
作者：
Daly Mb;C. Lerman
上皮性卵巢癌是美国女性中最常见的妇科癌症，每年有超过20，000例新诊断病例。这些患者中有70%以上患有晚期、III期或IV期疾病，每年导致13，000多人死亡。考虑到早期疾病的长期无病生存率约为85%，这一数字更加悲惨。该病的自然史尚不清楚，但其特征是起病隐匿，症状模糊，非特异性（通常被忽视），对目前的手术和化疗方法有很高但往往是短暂的反应。它通常与长期和痛苦的死亡伴随反复肠梗阻，营养不良和免疫妥协。除了受这种疾病影响的人的痛苦和生命损失之外，对经历这种损失的整个家庭也产生了深刻而持久的影响。
Epithelial ovarian cancer is the most common gynecologic cancer diagnosed in women in the United States, with over 20,000 newly diagnosed cases per year. Over 70% of these patients present with advanced, stage III or IV disease, resulting in more than 13,000 deaths each year. This figure is all the more tragic given the long-term disease-free survival of approximately 85% for early stage disease. The natural history of the disease is poorly understood but is characterized by an insidious onset with vague, non-specific symptoms (which are commonly overlooked), and a high but often transient response to current surgical and chemotherapeutic approaches. It is commonly associated with a prolonged and painful death accompanied by repeat bowel obstructions, malnutrition, and immunologic compromise. In addition to the pain and suffering and loss of life of those affected with the disease, there is a profound and long-lasting impact on the entire family who experience the loss.