Wnt signaling in breast cancer: have we come full circle?
Wnt signaling in breast cancer: have we come full circle?
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DOI：
10.1186/bcr321
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发表时间：
2001
影响因子：
7.4
通讯作者：
Brown, A M
中科院分区：
文献类型：
--
作者：
Brown, A M
自从最初在小鼠乳腺肿瘤病毒感染的小鼠中将Wnt 1鉴定为乳腺癌基因以来，一直有人质疑其与人类乳腺癌的相关性。目前已知Wnt 1是编码结构相似的分泌信号蛋白的Wnt基因大家族之一，其中一些是功能冗余的。近年来，这些蛋白质激活的主要细胞内信号通路已被阐明。该途径的组分包括原癌基因产物，如β-连环蛋白，和肿瘤抑制蛋白，如APC。尽管WNT 1本身与人类乳腺肿瘤无关，但据报道，其他WNT基因有时在人类乳腺癌中过表达，越来越多的证据表明，Wnt信号通路的下游成分在相当大比例的乳腺肿瘤中被激活。
Since the original identification of Wnt1 as a mammary oncogene in mouse mammary tumor virus infected mice, questions have been asked about its relevance to human breast cancer. Wnt1 is now known to be one of a large family of Wnt genes encoding structurally similar secreted signaling proteins, several of which are functionally redundant. The principal intracellular signaling pathway activated by these proteins has been elucidated in recent years. Components of this pathway include proto-oncogene products, such as β-catenin, and tumor suppressor proteins such as APC. Although WNT1 itself has not been implicated in human breast neoplasms, it has been reported that other WNT genes are sometimes overexpressed in human breast cancer and there is growing evidence that downstream components of the Wnt signaling pathway are activated in a significant proportion of breast tumors.