Rate of visual field loss in retinitis pigmentosa
Rate of visual field loss in retinitis pigmentosa
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DOI：
10.1016/s0161-6420(97)30291-7
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发表时间：
1997-03-01
期刊：
影响因子：
13.7
通讯作者：
Derlacki, DJ
中科院分区：
文献类型：
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作者：
Grover, S;Fishman, GA;Derlacki, DJ
目的：作者量化了色素性视网膜炎患者的视野丧失率，因为它与不同的临床领域表型相关。患者和方法：Goldmann 视野是在 77 名患者中使用目标 V-4e 获得的，并在 71 名患者中使用目标 II4e 获得的，这些患者患有孤立的或多种遗传类型的色素性视网膜炎，并且符合某些进入标准。根据视野丧失的模式，视野被分为五种不同的临床视野表型。使用用于分析纵向数据的混合模型方法来模拟视野面积的自然对数作为患者年龄和临床视野表型的函数。根据该分析的结果计算每个表型的视野区域的平均半衰期（测试剩余视野区域的一半的时间）。未分析具有正常临床视野表型（1 型）患者的视野数据。结果：与视野表型无关，靶点 V-4e 的平均半衰期值为 7.3 年，靶点 II4e 的平均半衰期为 6.8 年，没有统计学差异（P = 0.16）。具有部分或完全中周环暗点的视野（2型）和仅具有残余中心视野的视野（4型）的半衰期对于目标V-4e分别为9.5和9.4年，对于目标II4e分别为8.9和8.0年。部分周边限制（5 型）患者丧失视野，目标 V-4e 的半衰期为 9.5 年，目标 II4e 的半衰期为 7.3 年。对于靶标 V-4e 或 II4e，不同表型之间的半衰期差异均无统计学意义。具有残留中心区域和残留颞岛和/或鼻岛（3 型）的区域，靶标 V-4e 的半衰期为 4.8 年，靶标 II4e 的半衰期为 6.0 年。对于 V-4e 靶标，3 型和其他视野表型之间的半衰期差异具有统计学意义，但对于 II4e 靶标则不显着。结论：本研究的结果可用于咨询患有色素性视网膜炎和各种视野表型的患者有关其潜在视野丧失率的信息。
Purpose: The authors quantitate the rate of visual field loss in patients with retinitis pigmentosa as it relates to different clinical field phenotypes.Patients and Methods: Goldmann visual fields were obtained with target V-4e in 77 patients and with target II4e in 71 patients who had either isolated or various genetic types of retinitis pigmentosa and who met certain entrance criteria. The visual fields were categorized into five distinct clinical field phenotypes on the basis of their pattern of field loss. Mixed-model methods for the analysis of longitudinal data were used to model the natural logarithm of the visual field area as a function of patient age and clinical field phenotype. The average half-life (time over which half of the remaining field area would be test) of the visual field area for each phenotype was computed from the results of this analysis. Visual field data were not analyzed for patients with a normal clinical field phenotype (type 1).Results: Independent of the field phenotype, average half-life values were 7.3 years for target V-4e and 6.8 years for target II4e, which were not statistically different (P = 0.16). Visual fields with partial or complete midperipheral ring scotomas (type 2) and those with only a residual central field (type 4) had a half-life of 9.5 and 9.4 years, respectively, for target V-4e, and 8.9 and 8.0 years, respectively, for target II4e. Patients with partial peripheral restriction (type 5) lost visual fields with a half-life of 9.5 years for target V-4e and 7.3 years for target II4e. None of these differences in the half-lives between the different phenotypes were statistically significant for either targets V-4e or II4e. Fields with a residual central area and remaining temporal and/or nasal islands (type 3) had a half-life of 4.8 years for target V-4e and 6.0 years for target II4e. The differences in half-lives between type 3 and each of the other field phenotypes were statistically significant for the V-4e target, but not for the II4e target.Conclusions: The results of this study can be useful for counseling patients with retinitis pigmentosa and various visual field phenotypes as to their potential rate of visual field loss.