T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice.
T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice.
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DOI：
10.1084/jem.182.5.1567
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发表时间：
1995-11-01
期刊：
影响因子：
--
通讯作者：
Horak I
中科院分区：
文献类型：
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作者：
Ma A;Datta M;Margosian E;Chen J;Horak I
白细胞介素-2（IL-2）缺陷（IL-2-/-）小鼠发生贫血和结肠炎性肠病。为了阐明这种疾病的机制，我们将IL-2-/-小鼠与两种免疫缺陷小鼠品系，RAG-2-缺陷型（RAG-2-/-，缺乏B和T细胞）和JH-缺陷型小鼠（JH-/-，缺乏B细胞）交配。IL-2-/-、RAG-2-/-双突变小鼠无疾病，而IL-2-/-、JH-/-双突变小鼠以与IL-2-/-同窝出生的小鼠相同的速率死于肠病。然而，IL-2- /-、JH-/-小鼠不会死于贫血。因此，IL-2-/-小鼠的自发性肠道炎症需要成熟的T细胞，而不是B细胞，而贫血则依赖于B细胞。
Interleukin-2 (IL-2)-deficient (IL-2-/-) mice develop anemia and colonic inflammatory bowel disease. To elucidate the mechanism of this disease, we have bred IL-2-/- mice to two strains of immunodeficient mice, RAG-2-deficient (RAG-2-/-, lacking B and T cells) and JH- deficient mice (JH-/-, lacking B cells). IL-2-/-, RAG-2-/- double- mutant mice are disease free, while IL-2-/-, JH-/- double-mutant mice succumb to bowel disease at the same rate as IL-2-/- littermates. IL-2- /-, JH-/- mice do not, however, succumb to anemia. Thus, spontaneous intestinal inflammation in IL-2-/- mice requires mature T cells, not B cells, while anemia is dependent on B cells.