Association of C-reactive protein with markers of prevalent atherosclerotic disease
Association of C-reactive protein with markers of prevalent atherosclerotic disease
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DOI：
10.1016/s0002-9149(01)01603-4
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发表时间：
2001-07-15
影响因子：
2.8
通讯作者：
Eckfeldt, JH
中科院分区：
文献类型：
--
作者：
Folsom, AR;Pankow, JS;Eckfeldt, JH
最近的前瞻性研究表明，升高的c反应蛋白（CRP）是动脉粥样硬化血栓临床事件风险增加的标志。我们在一项大型的、横断面的家庭研究中（n = 875名男性，948名女性）检查了血清CRP是否与流行的冠心病（CHD）、踝/肱血压指数或颈动脉内膜-中膜厚度（一种通过b超评估的亚临床动脉粥样硬化指标）相关。CRP与许多其他心血管危险因素有关，特别是肥胖和胰岛素抵抗的标志，炎症和急性期反应的标志，以及激素替代疗法。经年龄和家庭类型调整后，CRP与男女患者颈动脉内膜-中膜厚度和女性冠心病患病率呈弱正相关。然而，对其他危险因素的调整完全消除了这种关联。例如，在女性中，经危险因素调整后的四分位数CRP内膜-中膜厚度平均值分别为0.76、0.74、0.75和0.76 mm （p < 0.05）。在男性中，CRP与踝关节/肱动脉血压指数呈弱负相关，独立于其他危险因素，但在女性中没有这种关联。我们的研究结果表明，CRP与流行的动脉粥样硬化没有强烈和独立的联系。由于CRP与临床事件相关，因此CRP升高可能是血栓形成风险的更强标志，而不是动脉粥样硬化程度的标志。(C) 2001年由摘录医学公司
Recent prospective studies have demonstrated that elevated C-reactive protein (CRP) is a marker of increased risk of atherothrombotic clinical events. We examined in a large, cross-sectional family-based study (n = 875 men, 948 women) whether serum CRP was associated with prevalent coronary heart disease (CHD), the ankle/brachial blood pressure index, or carotid intima-media thickness, an indicator of subclinical atherosclerosis as assessed by B-mode ultrasound. CRP was associated with many other cardiovascular risk factors, particularly markers of obesity and insulin resistance, markers of inflammation and acute phase reaction, and hormone replacement therapy. Adjusted for age and family type, there was a weak positive association of CRP with carotid intima-media thickness in both genders and with prevalent CHD in women. However, adjustment for other risk factors completely eliminated the associations. For example, among women, the risk factor-adjusted mean values of intima-media thickness across quartiles of CRP were 0.76, 0.74, 0.75, and 0.76 mm (p > 0.5). In men there was a weak inverse association between CRP and ankle/brachical blood pressure index, independent of other risk factors, but no such association in women. Our findings indicate that CRP is not strongly and independently associated with prevalent atherosclerosis. Because CRP has been associated with clinical events, it could be that elevated CRP may be a stronger marker of thrombotic risk than of the degree of atherosclerosis. (C) 2001 by Excerpta Medica, Inc.