Recombinant Amphiphilic Protein Micelles for Drug Delivery
Recombinant Amphiphilic Protein Micelles for Drug Delivery
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DOI：
10.1021/la202864x
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发表时间：
2011-12-06
期刊：
影响因子：
3.9
通讯作者：
Chaikof, Elliot L.
中科院分区：
文献类型：
--
作者：
Kim, Wookhyun;Xiao, Jiantao;Chaikof, Elliot L.
两亲性嵌段多肽可以在溶液中自组装成一系列纳米结构，包括胶束和囊泡。我们小组最近描述了重组两亲性二嵌段共聚肽形成高度稳定胶束的能力。在这份报告中，我们证明了蛋白质纳米粒子的效用，作为一种车辆控制药物输送。以具有抗炎活性的疏水性药物双嘧达莫为模型药物制备载药胶束。小鼠研究证实了载药蛋白胶束的能力，以限制在体内招募的中性粒细胞响应炎症刺激。
Amphiphilic block polypeptides can self-assemble into a range of nanostructures in solution, including micelles and vesicles. Our group has recently described the capacity of recombinant amphiphilic diblock copolypeptides to form highly stable micelles. In this report, we demonstrate the utility of protein nanoparticles to serve as a vehicle for controlled drug delivery. Drug-loaded micelles were produced by encapsulating dipyridamole as a model hydrophobic drug with anti-inflammatory activity. Murine studies confirmed the capacity of drug-loaded protein micelles to limit the in vivo recruitment of neutrophils in response to an inflammatory stimulus.