The European Prospective Investigation into Cancer and Nutrition (EPIC)
The European Prospective Investigation into Cancer and Nutrition (EPIC)
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DOI：
10.1590/s1135-57272004000200004
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发表时间：
2004-04-01
期刊：
影响因子：
--
通讯作者：
Berenguer, Antonio
中科院分区：
文献类型：
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作者：
González, Carlos A.;Navarro, Carmen;Berenguer, Antonio
EPIC 是一项前瞻性多中心研究，由世界卫生组织下属的国际癌症研究机构 (IARC) 协调，该研究于 1993 年开始，在 10 个欧洲国家（德国、丹麦、西班牙、法国、希腊、荷兰、意大利、挪威、英国和瑞典）的 23 个中心收集数据和血液样本。在西班牙，这项研究在五个地理区域（阿斯图里亚斯、格拉纳达、吉普斯夸、穆尔西亚和纳瓦拉）进行。这项研究总共包括 519,978 人（其中 366,521 人为女性），其中总共 385,719 人的血液样本可供实验室分析。迄今为止，总共已发现 24,195 例癌症病例。 2002 年欧洲营养杂志增刊上发表了 23 个欧洲中心的食物摄入量比较结果。关于饮食与癌症关系的初步EPIC结果显示，摄入纤维、水果和蔬菜有预防结肠癌和直肠癌的作用，摄入水果有预防肺癌的作用，摄入水果和蔬菜对上消化道有作用，而大量摄入水果和蔬菜对前列腺癌没有影响。使用七天日记来评估饱和脂肪摄入量，大量摄入饱和脂肪已被证明会增加患乳腺癌的风险。
EPIC is a prospective multi-center study coordinated by the International Agency for Research on Cancer (IARC) operating under the WHO which commenced in 1993 with the collecting of data and blood samples at twenty-three centers in ten European countries (Germany, Denmark, Spain, France, Greece, the Netherlands, Italy, Norway, the United Kingdom and Sweden). In Spain, this study was conducted in five geographic areas (Asturias, Granada, Guipuzcoa, Murcia and Navarre). This study included a total of 519,978 individuals (366,521 of whom were females), blood samples for laboratory analysis being available for a total of 385,719 of these individuals. To date, a total of 24,195 incident cancer cases have been identified. The results of the food intake comparison among the twenty-three European centers were published in 2002, in a European Nutrition journal supplement. The initial EPIC results concerning the relationship between diet and cancer show the intake of fiber, fruits and vegetables to have an effect on protect against colon and rectal cancer, the intake of fruits to have an effect on protect against lung cancer and the intake of fruits and vegetables on the upper digestive tract, whilst a high intake of fruits and vegetables has been shown to have no effect on prostate cancer. Using a seven-day diary for evaluating saturated fat intake, a high intake of saturated fats has been shown to increase the risk of breast cancer.