Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1α-MUC1 pathway
Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1α-MUC1 pathway
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DOI：
10.1016/j.canlet.2013.07.020
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发表时间：
2013-10-01
期刊：
影响因子：
9.7
通讯作者：
Hamada, Jun-ichi
中科院分区：
文献类型：
--
作者：
Goudarzi, Houman;Iizasa, Hisashi;Hamada, Jun-ichi
本研究观察了低氧对人恶性胸膜间皮瘤（MPM）细胞恶性程度的影响，发现：（1）低氧可增强人恶性胸膜间皮瘤（MPM）细胞的运动性和侵袭性，（2）这一现象可能是通过激活HIF-1通路，增加唾液酸化MUC 1的表达;（3）MUC 1启动子区的两个HIF结合位点对MUC 1在缺氧条件下的反式激活起重要作用。这些发现有助于更好地理解MPM细胞侵袭行为的分子机制，并在MPM患者的临床治疗中靶向它们。(C)2013爱思唯尔爱尔兰有限公司版权所有。
In this study, we examined the effects of hypoxia on the malignancy of human malignant pleural mesothelioma (MPM) cell lines, and found (I) hypoxia enhanced motility and invasiveness of human malignant pleural mesothelioma (MPM) cells; (2) this phenomenon resulted from increased expression of sialylated MUC1 through the activation of HIF-1 pathway; (3) two HIF-binding sites located in the promoter region of MUC1 were important for MUC1 transactivation under hypoxia. These findings are useful for better understanding molecular mechanisms of aggressive behavior of MPM cells and for targeting them in the clinical therapies for MPM patients. (C) 2013 Elsevier Ireland Ltd. All rights reserved.