Effects of probiotic administration on immune responses of children and adolescents with type 1 diabetes to a quadrivalent inactivated influenza vaccine
Effects of probiotic administration on immune responses of children and adolescents with type 1 diabetes to a quadrivalent inactivated influenza vaccine
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DOI：
10.1080/21645515.2019.1633877
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发表时间：
2019-07-25
影响因子：
4.8
通讯作者：
Esposito, Susanna
中科院分区：
文献类型：
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作者：
Bianchini, Sonia;Orabona, Ciriana;Esposito, Susanna
这项研究计划评估用鼠李糖乳杆菌GG（LGG）治疗3个月是否可以改变1型糖尿病（T1 D）儿童和青少年的免疫系统功能，从而增加对注射四价灭活流感疫苗（QIV）的免疫反应。共筛选了87名T1 D儿科患者，但益生菌组中有34名患者和对照组中有30名患者接受了QIV疫苗接种并完成了研究。研究了疫苗的免疫原性和安全性以及炎性细胞因子应答。结果表明，QIV在T1 D儿科患者中具有免疫原性和安全性，并且预先给予LGG三个月不会显著改变QIV体液免疫。QIV和LGG的组合降低了炎症反应（即，IFN-γ、IL-17 A、IL-17 F、IL-6和TNF-α），而不抑制血清保护性抗体的产生。总之，QIV在具有良好安全性特征的儿童和青少年T1 D患者中具有足够的免疫原性。虽然LGG的系统给药并没有导致对流感疫苗的体液应答的改善，但益生菌确实诱导了重要的抗炎作用。
This study was planned to evaluate whether a 3-month treatment with Lactobacillus rhamnosus GG (LGG) can modify immune system functions in children and adolescents with type 1 diabetes (T1D), leading to an increased immune response to an injectable quadrivalent inactivated influenza vaccine (QIV). A total of 87 pediatric patients with T1D were screened, although 34 patients in the Probiotic group and 30 in the Control group accepted to be vaccinated with QIV and completed the study. Vaccine immunogenicity and safety and the inflammatory cytokine response were studied. Results showed that QIV was immunogenic and safe in T1D pediatric patients and pre-administration of LGG for three months did not substantially modify the QIV humoral immunity. The combination of QIV and LGG reduced inflammatory responses (i.e., IFN-gamma, IL17A, IL-17F, IL-6, and TNF-alpha) from activated PBMCs of pediatric patients with T1D, without dampening the production of seroprotective antibodies. In conclusion, QIV is associated with an adequate immunogenicity in children and adolescents with T1D in presence of a good safety profile. Although a systematic administration of LGG did not result in an improvement of humoral responses to an influenza vaccine, the probiotic did induce important anti-inflammatory effects.