Reduced glutamate neurotransmission with Alzheimer's disease -: an in vivo 13C magnetic resonance spectroscopy study
Reduced glutamate neurotransmission with Alzheimer's disease -: an in vivo 13C magnetic resonance spectroscopy study
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DOI：
10.1007/s10334-003-0004-x
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发表时间：
2003-02-01
影响因子：
2.3
通讯作者：
Ross, BD
中科院分区：
文献类型：
--
作者：
Lin, AP;Shic, F;Ross, BD
阿尔茨海默氏病（AD）的认知障碍尚未得到充分解释。PET显示大脑葡萄糖代谢率降低。由于谷氨酸神经传递（GNT）消耗代谢产生的ATP的80%以上，基于GNT减少可能导致AD认知损害的假设，进行了初步研究以确定神经元三羧酸循环（TCA）。3例认知损害的AD患者（简易精神状态检查：24 vs 30，P
Cognitive impairment in Alzheimer's disease (AD) is not fully explained. PET indicates reduced cerebral metabolic rate for glucose. Since glutamate neurotransmission (GNT) consumes more than 80% of the ATP generated from metabolism, a pilot study was carried out to determine the neuronal tricarboxylic acid cycle (TCA) based on the hypothesis that reduced GNT could contribute to cognitive impairment in AD.Three AD patients with cognitive impairment (mini-mental state exam: 24 vs 30, P