A noninvasive functional lesion of the hypothalamo-pituitary axis for the study of growth hormone-releasing factor.
A noninvasive functional lesion of the hypothalamo-pituitary axis for the study of growth hormone-releasing factor.
复制标题
下丘脑-垂体轴的非侵入性功能性损伤，用于研究生长激素释放因子。
DOI：
10.1159/000123504
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发表时间：
1983
影响因子：
4.1
通讯作者：
Guillemin,R
中科院分区：
文献类型：
--
作者：
Wehrenberg,WB;Brazeau,P;Luben,R;Ling,N;Guillemin,R
Rats were passively immunized with an antiserum against somatostatin and a monoclonal antibody against rat hypothalamic growth hormone-releasing factor (rGRF-mAb) which does not recognize the biologically active 1–40 amino acid fragment of hpGRF-44 (hpGRF-40). Using this paradigm we have observed that the pituitary possesses a resilient capacity to release growth hormone (GH) following repeated injections of hpGRF-40 and that this response follows a dose-dependent relationship.
