Phylogenetics is the New Genetics (for Most of Biodiversity)
Phylogenetics is the New Genetics (for Most of Biodiversity)
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系统发育学是新的遗传学（对于大多数生物多样性而言）
DOI：
10.1016/j.tree.2020.01.005
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发表时间：
2020
影响因子：
16.8
通讯作者：
Edwards, Scott V.
中科院分区：
文献类型：
--
作者：
Smith, Stacey D.;Pennell, Matthew W.;Dunn, Casey W.;Edwards, Scott V.
尽管在理解形态、生理和行为差异的遗传基础方面取得了实质性进展，但许多感兴趣的表型难以用传统的遗传方法进行研究，因为它们的起源可以追溯到生命之树的深层节点。此外，许多物种既不适合大规模取样，也不适合实验室杂交。我们认为，系统发育的方法和理论提供了巨大的力量，以确定潜在的性状进化的功能遗传变异。我们预计，现有的统计比较方法将更普遍地应用于研究表型进化的遗传基础，因为整个基因组继续填充生命之树。然而，需要新的方法和途径来充分利用分支规模基因组数据集的力量。
Despite substantial progress in understanding the genetic basis for differences in morphology, physiology, and behavior, many phenotypes of interest are difficult to study with traditional genetic approaches because their origin traces to deep nodes in the tree of life. Moreover, many species are not amenable to either large-scale sampling or laboratory crosses. We argue that phylogenetic methods and theory provide tremendous power to identify the functional genetic variation underlying trait evolution. We anticipate that existing statistical comparative approaches will be more commonly applied to studying the genetic basis for phenotypic evolution as whole genomes continue to populate the tree of life. Nevertheless, new methods and approaches will be needed to fully capitalize on the power of clade-scale genomic datasets.