Vitamin B6 intake and incidence of diabetic retinopathy in Japanese patients with type 2 diabetes: analysis of data from the Japan Diabetes Complications Study (JDCS)
Vitamin B6 intake and incidence of diabetic retinopathy in Japanese patients with type 2 diabetes: analysis of data from the Japan Diabetes Complications Study (JDCS)
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DOI：
10.1007/s00394-019-02014-4
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发表时间：
2020-06-01
影响因子：
5
通讯作者：
Sone, Hirohito
中科院分区：
文献类型：
--
作者：
Horikawa, Chika;Aida, Rei;Sone, Hirohito
虽然维生素B6被怀疑可以预防糖尿病视网膜病变的进展，但基于纵向研究的2型糖尿病患者的证据很少。本研究调查了日本2型糖尿病患者维生素B6摄入量与糖尿病视网膜病变发病率之间的关系。方法本研究是对全国范围内年龄在40-70岁之间、HbA 1c ≥ 48 mmol/mol的2型糖尿病患者队列研究的一部分。在排除了无应答者的饮食调查使用的食物频率问卷的基础上的食物组，978例患者进行了分析。主要结局是糖尿病视网膜病变事件的8年风险，考克斯回归分析根据年龄、性别、体重指数、HbA 1c、吸烟、能量摄入和其他混杂因素调整的维生素B6摄入量估计视网膜病变的风险比（HR）。结果四分位数的平均维生素B6摄入量范围为1.1至1.6 mg/天，一半的参与者的维生素B6摄入量低于日本成年人膳食参考摄入量（男性1.4 mg/天;女性1.2 mg/天）的推荐每日膳食允许量。校正混杂因素后，维生素B6摄入量的第2、3和4四分位数组与第1四分位数组相比，糖尿病视网膜病变的HR为1.17（95%置信区间0.81-1.69，p = 0.403）、0.88（0.58-1.34，p = 0.550）和0.50（0.30-0.85，p = 0.010）。结论研究结果表明，高维生素B6摄入量与日本2型糖尿病患者糖尿病视网膜病变的发病率较低相关。
Purpose Although vitamin B6 has been suspected to prevent the progression of diabetic retinopathy, evidence of this in patients with type 2 diabetes based on longitudinal studies is sparse. This study investigated the relationship between vitamin B6 intake and the incidence of diabetic retinopathy in Japanese patients with type 2 diabetes. Methods The study was part of an examination of a nationwide cohort of patients with type 2 diabetes aged 40-70 years with HbA1c >= 48 mmol/mol. After excluding nonresponders to a dietary survey using the Food Frequency Questionnaire based on food groups, 978 patients were analyzed. Primary outcome was the 8-year risk of a diabetic retinopathy event, and Cox regression analyses estimated hazard ratios (HRs) for retinopathy according to vitamin B6 intake adjusted for age, gender, body mass index, HbA1c, smoking, energy intake, and other confounders. Results Mean vitamin B6 intake in quartiles ranged from 1.1 to 1.6 mg/day, and half of the participants had vitamin B6 intake below the recommended daily dietary allowance according to dietary reference intakes in Japanese adults (men 1.4 mg/day; women 1.2 mg/day). After adjusting for confounders, HRs for diabetic retinopathy in the 2nd, 3rd, and 4th quartile groups of vitamin B6 intake compared with the 1st quartile group were 1.17 (95% confidence interval 0.81-1.69, p = 0.403), 0.88 (0.58-1.34, p = 0.550), and 0.50 (0.30-0.85, p = 0.010), respectively. Conclusions Findings suggested that high vitamin B6 intake was associated with a lower incidence of diabetic retinopathy in Japanese with type 2 diabetes.