White blood cell and hormonal responses to 4300 m altitude before and after intermittent altitude exposure
White blood cell and hormonal responses to 4300 m altitude before and after intermittent altitude exposure
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DOI：
10.1042/cs20060012
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发表时间：
2006-08-01
期刊：
影响因子：
6
通讯作者：
Skrinar, Gary S.
中科院分区：
文献类型：
--
作者：
Beidleman, Beth A.;Muza, Stephen R.;Skrinar, Gary S.
最近的研究表明，短暂的每日IAE（间歇性高原暴露）是同样有效的连续高原居住在诱导生理适应与高原习服一致。虽然IAE的积极益处已经明确界定，但IAE对健康，特别是免疫系统的潜在负面影响仍然不明确。本研究确定了在海拔4300 m的休息和运动期间IAE对WBC（白色血细胞）和激素反应的影响。6名低地人（年龄，23 +/- 2岁;体重，77 +/- 6 kg;数值为平均值+/- S.E.M.）在30小时SL（海平面）暴露期间以及在30小时暴露于4300 m海拔等效高度期间完成Vo（2）max（最大O-2摄取量）和次最大踏车测力计测试，一次在3周IAE（4小时）之前（PreIAE）和之后（PostIAE）。天（-1），5天（.）week（-1），4300 m）。次极量踏车测力计测试包括两次连续15分钟的工作，分别为海拔特定Vo（2）max的40%和70%。在休息时和两次运动工作期间采集血样，用于测量WBC计数、白细胞亚群计数、皮质醇、肾上腺素（肾上腺素）和去甲肾上腺素（去甲肾上腺素）。白细胞、中性粒细胞和淋巴细胞计数从SL到PreIAE在安静和运动时显著升高（P < 0.05），从PreIAE到PostIAE在安静和运动时显著降低（P < 0.05）。从IAE前到IAE后，单核细胞计数在休息和运动期间下降（P < 0.05），但嗜酸性粒细胞和嗜碱性粒细胞计数没有变化。皮质醇、肾上腺素和去甲肾上腺素在休息或运动期间从SL到PreIAE或PostIAE没有变化，但在两次工作回合中从休息开始均显著增加（P < 0.05）。总之，这种类型的IAE刺激不会诱导激素应激反应，并且在海拔高度激活免疫系统方面没有损害，如通过WBC和白细胞亚群计数所测量的。因此，高度推荐这种预适应方法用于诱导高原适应，而无需“高原居住”要求。
Recent studies have demonstrated that brief daily IAE (intermittent altitude exposure) was equally as effective as continuous altitude residence in inducing physiological adaptations consistent with altitude acclimatization. Although the positive benefits of IAE have been clearly defined, the potential negative consequences of IAE on health, specifically the immune system, remain undefined. The present study determined the effects of IAE on WBC (white blood cell) and hormonal responses during rest and exercise at 4300 m altitude. Six lowlanders (age, 23 +/- 2 years; body weight, 77 +/- 6 kg; values are means +/- S.E.M.) completed a Vo(2)max (maximal O-2 uptake) and submaximal cycle ergometer test during a 30-h SL (sea level) exposure and during a 30 h exposure to 4300 m altitude-equivalent once before (PreIAE) and once after (PostIAE) a 3-week period of IAE (4 h (.) day(-1), 5 days (.) week(-1), 4300 m). The submaximal cycle ergometer test consisted of two consecutive 15-min work bouts at 40% and 70% of altitude-specific Vo(2)max. Blood samples were obtained at rest and during both exercise work bouts for measurements of WBC count, leucocyte subset counts, cortisol, adrenaline (epinephrine) and noradrenaline (norepinephrine). WBC, neutrophil and lymphocyte counts increased significantly (P < 0.05) during rest and exercise from SL to PreIAE and decreased (P < 0.05) during rest and exercise from PreIAE to PostIAE. Monocyte counts decreased (P < 0.05) during rest and exercise from PreIAE to PostIAE, but eosinophil and basophil counts did not change. Cortisol, adrenaline and noradrenaline did not change during rest or exercise from SL to PreIAE or PostIAE, but all increased significantly (P < 0.05) from rest during the two work bouts. In conclusion, this type of IAE stimulus did not induce a hormonal stress response and did no harm in terms of activation of the immune system at altitude, as measured by WBC and leucocyte subset counts. This method of pre-acclimatization can therefore be highly recommended for inducing altitude acclimatization without the 'altitude residency' requirement.