Mesenchymal stem cell mechanobiology.
Mesenchymal stem cell mechanobiology.
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DOI：
10.1007/s11914-010-0015-2
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发表时间：
2010-06-01
影响因子：
4.3
通讯作者：
Jacobs, Christopher R
中科院分区：
文献类型：
--
作者：
Castillo, Alesha B;Jacobs, Christopher R
骨髓来源的多能干细胞和基质细胞（MSC）可能是针对包括骨骼疾病在内的各种疾病的细胞疗法的候选者。这些疗法的进步将依赖于以安全有效的方式识别、分离、操纵和输送干细胞的能力。尽管物理信号明显影响组织形态发生、干细胞分化和愈合过程，但机械诱导的信号事件的整合仍然不清楚。干细胞对机械信号的感觉和解释的机制是深入研究的焦点。外部机械信号能够激活 MSC 中的成骨信号通路，包括 Wnt、Ror2 和 Runx2。同样清楚的是，细胞-细胞外基质相互作用产生的细胞内张力在 MSC 调节中发挥着关键作用。需要进一步的工作来确定机械力在干细胞功能中发挥的精确作用。
Bone marrow-derived multipotent stem and stromal cells (MSCs) are likely candidates for cell-based therapies for various conditions including skeletal disease. Advancement of these therapies will rely on an ability to identify, isolate, manipulate, and deliver stem cells in a safe and effective manner. Although it is clear that physical signals affect tissue morphogenesis, stem cell differentiation, and healing processes, integration of mechanically induced signaling events remain obscure. Mechanisms underlying sensation and interpretation of mechanical signals by stem cells are the focus of intense study. External mechanical signals have the ability to activate osteogenic signaling pathways in MSCs including Wnt, Ror2, and Runx2. It is also clear that intracellular tensile forces resulting from cell-extracellular matrix interactions play a critical role in MSC regulation. Further work is required to determine the precise role that mechanical forces play in stem cell function.