Characterization Tools for Mechanical Probing of Biomimetic Materials
Characterization Tools for Mechanical Probing of Biomimetic Materials
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DOI：
10.1007/978-3-662-59596-1_2
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发表时间：
2019-01-01
期刊：
影响因子：
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通讯作者：
Vassalli, Massimo
中科院分区：
文献类型：
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作者：
Caponi, Silvia;Canale, Claudio;Vassalli, Massimo
完全治愈受损或衰竭的组织和器官的可能性是现代医学的主要挑战之一。已经提出了几种方法，或者使用组织工程功能替代品，或者诱导身体自我修复，利用其固有的再生潜力。在任何情况下，治疗成功的关键步骤是通过设计合适的支架来提供，该支架能够维持细胞生长并诱导向感兴趣的谱系分化。越来越多的证据表明，设计有效支架的最经济的方法是利用仿生方法，试图模仿自然环境的特征。此外，已经指出，不仅材料的化学性质与该过程有关，而且其物理特性，特别是机械特性也与该过程有关。绘制活组织的弹性在下一代仿生支架的合理设计中变得越来越重要，并且需要利用先进的工具来实现亚微米分辨率，与单个活细胞探测的长度尺度相当。
The possibility to fully heal damaged or failing tissues and organs is one of the major challenges of modern medicine. Several approaches have been proposed, either using tissue engineered functional substitutes or inducing the body to self-repair, exploiting its innate regenerative potential. In any case, a crucial step for the success of therapy is provided by the design of a suitable scaffold, capable to sustain cellular growth and induce the differentiation towards the lineage of interest. A growing body of evidence suggests that the most affordable way to design an effective scaffold is to exploit a biomimetic approach, trying to emulate the characteristics of the natural environment. Moreover, it has been pointed out that not only the chemical nature of the material is relevant to this process but also its physical and, in particular, mechanical properties. Mapping the elasticity of a living tissue is becoming more and more relevant in the rational design of next generation biomimetic scaffolds, and the exploitation of advanced tools is required to achieve sub-μm resolution, comparable to the length scale probed by a single living cell.