Level of circulating PD-L1 expression in patients with advanced gastric cancer and its clinical implications
Level of circulating PD-L1 expression in patients with advanced gastric cancer and its clinical implications
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DOI：
10.3978/j.issn.1000-9604.2014.02.08
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发表时间：
2014-02-01
影响因子：
5.1
通讯作者：
Ji, Jiafu
中科院分区：
文献类型：
--
作者：
Zheng, Zhixue;Bu, Zhaode;Ji, Jiafu
目的：程序性细胞死亡-1受体/程序性细胞死亡-1配体（PD-1/PD-L1）通路在肿瘤逃避宿主免疫中起着至关重要的作用。本研究旨在探讨PD-L1表达与进展期胃癌患者预后的关系。通过酶联免疫吸附试验（ELISA）检测循环PD-L1表达。结果：PD-L1在进展期胃癌组织中的表达水平明显高于正常对照组（P=0.006）。PD-L1的表达与胃癌的分化程度和淋巴结转移密切相关（P=0.026和P=0.041）。虽然PD-L1不同表达的进展期胃癌患者之间差异无统计学意义，但PD-L1高表达的腺癌患者预后明显好于低表达的腺癌患者（65.6% vs. 44.7%，P=0.028）。PD-L1在晚期胃癌患者中升高，可能在肿瘤免疫逃避和患者预后中发挥重要作用。
Objective: The programmed cell death-1 receptor/programmed cell death-1 ligand (PD-1/PD-L1) pathway plays a crucial role in tumor evasion from host immunity. This study was designed to evaluate the association between circulating PD-L1 expression and prognosis in patients with advanced gastric cancer.Methods: Totally 80 advanced gastric cancer patients and 40 health controls from Beijing Cancer Hospital were enrolled in the present study. Circulating PD-L1 expression was tested by enzyme-linked immunosorbent assay (ELISA). The associations between the expression level of PD-L1 and clinicopathological features and prognosis were analyzed statistically.Results: Expression of PD-L1 in advanced gastric cancer patients was significantly up-regulated compared with health people (P=0.006). The expression of PD-L1 was significantly correlated with differentiation and lymph node metastasis (P=0.026 and P=0.041, respectively). Although we didn't find significant difference in all advanced gastric cancer patients with different PD-L1 expression, the adenocarcinoma patients with higher up-regulated PD-L1 expression had much better prognosis than low expression patients (65.6% vs. 44.7%, P=0.028).Conclusions: PD-L1 was elevated in advance gastric cancer patients and may play an important role in tumor immune evasion and patients prognosis.