Characterization of microenvironmental changes in the intervertebral discs of patients with chronic low back pain using multiparametric MRI contrasts extracted from Z-spectrum.
Characterization of microenvironmental changes in the intervertebral discs of patients with chronic low back pain using multiparametric MRI contrasts extracted from Z-spectrum.
复制标题
使用从 Z 谱中提取的多参数 MRI 对比来表征慢性腰痛患者椎间盘的微环境变化。
DOI：
10.1007/s00586-021-06733-3
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Cai,Kejia
中科院分区：
文献类型：
--
作者：
Li,Li;Zhou,Zhiguo;Xiong,Wei;Fang,Jicheng;Scotti,Alessandro;Shaghaghi,Mehran;Zhu,WenZhen;Cai,Kejia
PurposeZ-spectrum MRI数据进行分析，以产生多参数代谢和微环境对比，用于识别椎间盘有/无疼痛症状和sore pain. MethodsZ-spectrum数据收集自26例非特异性慢性腰痛（CLBP）和21例无症状对照（AC）的腰椎间盘，采用化学交换饱和转移（CEST）。数据进行了拟合，以量化CEST的影响，从糖胺聚糖，酰胺质子转移（APT），核欧沃豪泽增强（NOE），半固体磁化传递对比效应，和水的直接饱和。从拟合的峰值振幅计算多参数图，并从所有五个木材圆盘计算平均值。结果有症状患者的椎间盘含水量、胶原结合水和胶原含量均低于AC组（P <0. 05），而有症状患者的椎间盘含水量、胶原结合水和胶原含量低于AC组（P<0. 05）。此外，Z-频谱MRI表明，与Nsore亚组相比，疮亚组中的椎间盘具有更少的水、胶原结合水和胶原，并且可能具有更低的pH值（P< 0.05）。较低的pH值（以减少APT和NOE效应来衡量）可能是导致背部酸痛的一个重要病理因素。结论Z谱MRI及其多参数代谢和微环境对比已被证明可以识别有和没有疼痛症状或酸痛的椎间盘，提供更重要的信息CLBP。
PurposeZ-spectral MRI data were analyzed to produce multiparametric metabolic and microenvironmental contrasts for identifying intervertebral discs with/without pain symptom and sore pain.MethodsZ-spectra data were collected from the lumbar discs of 26 patients with non-specific chronic low bck pain (CLBP) and 21 asymptomatic controls (AC) with a chemical exchange saturation transfer (CEST). Data were fitted to quantify the CEST effects from glycosaminoglycan, amide proton transfer (APT), nuclear Overhauser enhancement (NOE), semi-solid magnetization transfer contrast effects, and the direct saturation of water. Multiparametric maps were computed from the fitted peak amplitudes, and the average values were calculated from all five lumber discs. Those parameters were compared between the CLBP and AC groups and between the subgroups with and without (Nsore) sore pain.ResultsThe discs in symptomatic patients have lower water content, collagen-bound water and collagen than the discs in AC (P< 0.05). Additionally, Z-sepctral MRI indicated that the discs in the sore subgroup had less water, collagen-bound water and collagen, and likely lower pH compared to the Nsore subgroup (P< 0.05). Lower pH as measured with reduced APT and NOE effects may be an important pathological factor causing sore pain of the back.ConclusionZ-spectral MRI with its multiparametric metabolic and microenvironmental contrasts has been demonstrated to identify discs with and without pain symptom or sore pain, providing more important information of CLBP.