The ESCRT machinery: new roles at new holes.
The ESCRT machinery: new roles at new holes.
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ESCRT机械：新洞的新角色。
DOI：
10.1016/j.ceb.2015.12.001
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发表时间：
2016-02
影响因子：
7.5
通讯作者：
Carlton JG
中科院分区：
文献类型：
--
作者：
Olmos Y;Carlton JG
ESCRT机制驱动多种膜重塑事件，包括多泡体生物发生、包膜逆转录病毒的释放以及有丝分裂退出期间核膜的重新形成和细胞动力学破坏。这些事件都需要一个拓扑等效的膜重塑来完成，而ESCRT机制在这些不同背景下的细胞部署突出了其作为转座膜裂变机制的功能。在这里，我们将检查最近的数据描述ESCRT-III依赖膜重塑和探索ESCRT-III复合物在核膜的新角色。
The ESCRT machinery drives a diverse collection of membrane remodeling events, including multivesicular body biogenesis, release of enveloped retroviruses and both reformation of the nuclear envelope and cytokinetic abscission during mitotic exit. These events share the requirement for a topologically equivalent membrane remodeling for their completion and the cells deployment of the ESCRT machinery in these different contexts highlights its functionality as a transposable membrane-fission machinery. Here, we will examine recent data describing ESCRT-III dependent membrane remodeling and explore new roles for the ESCRT-III complex at the nuclear envelope.