Maternal antenatal anxiety and behavioural/emotional problems in children: a test of a programming hypothesis
Maternal antenatal anxiety and behavioural/emotional problems in children: a test of a programming hypothesis
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DOI：
10.1111/1469-7610.00187
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发表时间：
2003-10-01
期刊：
影响因子：
--
通讯作者：
Glover, V
中科院分区：
文献类型：
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作者：
O'Connor, TG;Heron, J;Glover, V
背景：先前的动物研究将产前应激与后代的一系列持续性行为异常联系起来。目前的研究检查了这种影响是否也在人类中发现，直到童年中期。研究方法：目前的研究是基于雅芳父母和儿童纵向研究（ALSPAC），这是一项前瞻性的，以社区为基础的研究，跟踪了一组怀孕妇女。母亲的焦虑和抑郁的自我报告措施进行了评估，在重复的间隔在怀孕和产后期间。在47岁和81个月时，通过父母报告评估儿童的行为/情绪问题。在怀孕和产后期间的几个时间点获得了有关产科和心理社会因素的信息。结果如下：在控制了产科风险、心理社会不利因素以及产后焦虑和抑郁因素后，母亲在妊娠后期经历高水平焦虑的儿童在81个月时表现出更高的行为/情绪问题发生率（女孩OR = 1.91，95%CI = 1.26-2.89;男孩OR = 2.16，95%CI = 1.41-3.30）。此外，81个月时的效果与之前47个月时获得的效果相当，这表明动物文献中提出的持续效果。结论：有证据表明，产前压力/焦虑对胎儿有编程影响，至少持续到童年中期。
Background: Previous animal investigations link antenatal stress with a range of persistent behavioural abnormalities in the offspring. The current study examined if the effect was also found in humans through middle childhood. Methods: The current study is based on the Avon Longitudinal Study of Parents and Children (ALSPAC), a prospective, community-based study that has followed a cohort of women from pregnancy. Self-report measures of maternal anxiety and depression were assessed at repeated intervals in pregnancy and the postnatal period. Children's behavioural/emotional problems were assessed by parent report at age 47 and 81 months. Information on obstetric and psychosocial factors was obtained at several points in pregnancy and the postnatal period. Results: Children whose mothers experienced high levels of anxiety in late pregnancy exhibited higher rates of behavioural/emotional problems at 81 months of age after controlling for obstetric risks, psychosocial disadvantage, and postnatal anxiety and depression (for girls, OR = 1.91, 95%CI = 1.26-2.89; for boys, OR 2.16, 95%CI = 1.41-3.30). Furthermore, the effect at 81 months was comparable to what was previously obtained at 47 months, suggesting the kind of persistent effect proposed in the animal literature. Conclusions: There is evidence that antenatal stress/anxiety has a programming effect on the fetus which lasts at least until middle childhood.