SOME EFFECTS OF D-AMPHETAMINE, CAFFEINE, NICOTINE AND COCAINE ON SCHEDULE-CONTROLLED RESPONDING OF THE MOUSE
SOME EFFECTS OF D-AMPHETAMINE, CAFFEINE, NICOTINE AND COCAINE ON SCHEDULE-CONTROLLED RESPONDING OF THE MOUSE
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DOI：
10.1016/0028-3908(86)90160-7
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发表时间：
1986-10-01
影响因子：
4.7
通讯作者：
GLOWA, JR
中科院分区：
文献类型：
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作者：
GLOWA, JR
比较了 d-苯丙胺 (0.03-10.0 mg/kg)、咖啡因 (0.3-100.0 mg/kg)、尼古丁 (0.003-10.0 mg/kg) 和可卡因 (0.03-56.0 mg/kg) 对小鼠在三种不同食物呈现方案下维持的反应的影响。 d-苯丙胺、尼古丁和可卡因的累积剂量仅降低在固定比率 30 响应、固定间隔 60 秒和固定间隔 60 秒时间表以及惩罚意外事件（抑制响应）下维持的响应。在大多数情况下，药物的 ED50（使反应降低 50% 的剂量）与每个方案下维持的反应率之间存在反比关系。例外情况是，(i) 对于 d-苯丙胺和可卡因，抑制响应的 ED50 小于非抑制固定间隔响应的 ED50。相反，中等剂量的咖啡因增加了抑制反应，对固定间隔反应影响不大，并降低了固定比例反应。在研究条件范围内效果的差异表明，精神运动兴奋剂的行为效果可用于检查每种药物作用机制的潜在差异。这些发现可能有助于理解精神运动兴奋剂的神经药理学和行为效应之间的关系。
The effects of d-amphetamine (0.03-10.0 mg/kg), caffeine (0.3-100.0 mg/kg), nicotine (0.003-10.0 mg/kg) and cocaine (0.03-56.0 mg/kg) were compared on responding maintained under three different schedules of food presentation in mice. Cumulative doses of d-amphetamine, nicotine and cocaine only decreased responding maintained under fixed-ratio 30 response, fixed-interval 60-sec and fixed-interval 60 sec schedules with a punishment contingency (suppressed responding). In most cases there was an inverse relationship between the ED50 (dose which decreased responding by 50%) for the drug and the rate of responding maintained under each schedule. The exceptions were, (i) with both d-amphetamine and cocaine the ED50 for suppressed responding was smaller than that for non-suppressed fixed-interval responding. In contrast, the intermediate doses of caffeine increased suppressed responding, had little effect on fixed-interval responding and decreased fixed-ratio responding. This difference in profile of effect over the range of conditions studied, suggests that the behavioral effects of psychomotor stimulants can be used to examine potential differences in the mechanisms of action of each drug. Such findings may aid in the understanding of the relationships between the neuropharmacological and behavioral effects of psychomotor stimulant drugs.