Sequence-Mandated, Distinct Assembly of Giant Molecules
Sequence-Mandated, Distinct Assembly of Giant Molecules
复制标题
巨分子的序列规定的独特组装
DOI：
10.1002/anie.201709354
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发表时间：
2017
影响因子：
16.6
通讯作者：
Cheng Stephen Z. D.
中科院分区：
文献类型：
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作者：
Zhang Wei;Lu Xinlin;Mao Jialin;Hsu Chih-Hao;Mu Gaoyan;Huang Mingjun;Guo Qingyun;Liu Hao;Wesdemiotis Chrys;Li Tao;Zhang Wen-Bin;Li Yiwen;Cheng Stephen Z. D.
虽然控制合成聚合物的一级结构本身就是一个巨大的挑战，但序列控制用于定制分级结构的潜力仍有待开发，特别是在创造新的和非常规的相方面。设计并合成了一系列模型两亲性链状巨分子，通过将疏水性和亲水性分子纳米颗粒以精确定义的顺序和组成相互连接，研究了它们的序列依赖性相结构。不仅组成的变化改变了自组装的超分子相，而且特定的序列诱导非常规相的形成，包括Frank-Kasper相。形成机制归因于由集体氢键和分子的序列授权拓扑结构驱动的构象变化。这些结果表明，合成聚合物中的序列控制可以对聚合物性能和自组装产生显著影响。
Although controlling the primary structure of synthetic polymers is itself a great challenge, the potential of sequence control for tailoring hierarchical structures remains to be exploited, especially in the creation of new and unconventional phases. A series of model amphiphilic chain‐like giant molecules was designed and synthesized by interconnecting both hydrophobic and hydrophilic molecular nanoparticles in precisely defined sequence and composition to investigate their sequence‐dependent phase structures. Not only compositional variation changed the self‐assembled supramolecular phases, but also specific sequences induce unconventional phase formation, including Frank–Kasper phases. The formation mechanism was attributed to the conformational change driven by the collective hydrogen bonding and the sequence‐mandated topology of the molecules. These results show that sequence control in synthetic polymers can have a dramatic impact on polymer properties and self‐assembly.