Amelioration of effects of hypertension and diabetes on myocardium by cardiac glycoside.
Amelioration of effects of hypertension and diabetes on myocardium by cardiac glycoside.
复制标题
强心苷改善高血压和糖尿病对心肌的影响。
DOI：
10.1152/ajpheart.1992.262.3.h734
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Anversa,P
中科院分区：
文献类型：
--
作者：
Capasso,JM;Puntillo,E;Halpryn,B;Olivetti,G;Li,P;Anversa,P
为了确定地高辛是否在高血压和糖尿病合并的初始阶段保护心肌，患有两肾一夹肾性高血压和链脲佐菌素诱导的糖尿病的成年雄性Wistar大鼠在高血压和糖尿病发作后立即用地高辛（500 μ g·kg-1·d-1）灌胃治疗10周。测量体循环动脉压、心室压、左心室压一阶导数、舒张期室壁应力，定量分析心肌病变的数量、分布及心肌毛细血管密度。与未治疗的高血压-糖尿病动物相比，地高辛治疗的大鼠显示左心室舒张末期压和舒张期和收缩期壁应力的升高较小，尽管高血压和血糖水平的程度相当。此外，在用该糖苷处理的动物中，室直径较小，氧气扩散距离在正常值范围内。然而，替代性纤维化病灶的数密度与未治疗的高血压-糖尿病动物相似。总之，地高辛降低了高血压和糖尿病模型中心室重构和舒张期室壁应力的大小。
To determine whether digoxin protects the myocardium during the initial phases of hypertension and diabetes combined, adult male Wistar rats with two-kidney, one-clip renal hypertension and streptozotocin-induced diabetes mellitus were treated with digoxin (500 micrograms.kg-1.day-1) by gavage for 10 wk immediately after the onset of hypertension and diabetes. Systemic arterial blood pressures, ventricular pressures, the first time derivative of left ventricular pressure, diastolic wall stress, and the quantitative analysis of the number and distribution of myocardial lesions and capillary density of the myocardium were measured. In comparison to untreated hypertensive-diabetic animals, digoxin-treated rats showed a lesser elevation in left ventricular end-diastolic pressure and diastolic and systolic wall stress despite comparable degrees of hypertension and blood glucose levels. In addition, chamber diameter was smaller and the diffusion distance for oxygen was within normal values in animals treated with this glycoside. However, the numerical density of the foci of replacement fibrosis was similar to that found in untreated hypertensive-diabetic animals. In conclusion, digoxin reduces the magnitude of ventricular remodeling and diastolic wall stress in this model of hypertension and diabetes.