Randomised placebo-controlled trial of use of topical recombinant bovine basic fibroblast growth factor for second-degree burns
Randomised placebo-controlled trial of use of topical recombinant bovine basic fibroblast growth factor for second-degree burns
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DOI：
10.1016/s0140-6736(98)01260-4
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发表时间：
1998-11-21
期刊：
影响因子：
168.9
通讯作者：
Sheng, ZY
中科院分区：
文献类型：
--
作者：
Fu, XB;Shen, ZY;Sheng, ZY
背景：创面愈合是一个动态的过程，可以被生长因子加速。在一项随机安慰剂对照试验中，我们观察了重组牛碱性成纤维细胞生长因子(RbFGF)对烧伤愈合的影响。患者每天接受150AU/cm(2)局部rbFGF(n=300)或安慰剂(n=300)加赋形剂治疗。我们通过摄影、穿孔活检和临床检查来评估愈合情况，发现所有接受rbFGF治疗的患者都比安慰剂组有更快的肉芽组织形成和表皮再生。浅、深二度烧伤创面愈合时间分别为9.9d(SD2.5d)和17.0d(4.6d)，分别为12.4d(2.7d)和21.2d(4.9d)(p=0.0008和p=0.0003)。RbFGF未见局部或全身不良反应。解释rbFGF可有效缩短愈合时间，提高愈合质量。临床上的好处是缩短了医院的屠宰时间，患者的皮肤很快就可以采集和移植了。
Background Wound healing is a dynamic process that could be accelerated by growth factors. We investigated the effect of recombinant bovine basic fibroblast growth factor (rbFGF) on burn healing in a randomised placebo-controlled trial.Methods We recruited 600 patients with superficial or deep second-degree burns. Patients received 150 AU/cm(2) daily topical rbFGF (n=300) or placebo (n=300) plus vehicle. We assessed healing by photography, punch-biopsy, and clinical examination.Findings All patients treated with rbFGF had faster granulation tissue formation and epidermal regeneration than those in the placebo group. Superficial and deep second-degree burns treated with rbFGF healed in a mean of 9 9 (SD 2.5) days and 17.0 (4.6) days, respectively, compared with 12.4 (2.7) and 21.2 (4.9) days (p=0.0008 and p=0.0003, respectively). No adverse effects were seen locally or systemically with rbFGF.Interpretation rbFGF effectively decreased healing time and improved healing quality. Clinical benefits would be shorter hospital slays and the patient's skin quickly becoming available for harvesting and grafting.