Advances in mechanisms of asthma, allergy, and immunology in 2010
Advances in mechanisms of asthma, allergy, and immunology in 2010
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DOI：
10.1016/j.jaci.2011.01.027
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发表时间：
2011-03-01
影响因子：
14.2
通讯作者：
Rothenberg, Marc E.
中科院分区：
文献类型：
--
作者：
Broide, David H.;Finkelman, Fred;Rothenberg, Marc E.
2010年的标志是我们对过敏性炎症和哮喘发病机制所涉及的细胞和分子机制的理解取得了快速进展。发表在《过敏和临床免疫学杂志》上的研究描述了我们对与过敏性炎症相关的细胞（肥大细胞、嗜酸性粒细胞、树突状细胞和T细胞）以及IgE、细胞因子、受体、信号分子和通路的认识的进展。研究使用动物模型以及人体细胞和组织，以促进我们对哮喘、嗜酸性食管炎、食物过敏、过敏反应和速发型超敏反应、肥大细胞及其疾病、特应性皮炎、鼻息肉病和嗜酸性粒细胞增多综合征机制的理解。其他研究提供了关于过敏性炎症的诱导和调节以及过敏性炎症的遗传贡献的新信息。这些研究的关键特征及其对人类特应性疾病的潜在影响总结在这里。（J Allergy Clin Immunol 2011;127：689-95.）
2010 was marked by rapid progress in our understanding of the cellular and molecular mechanisms involved in the pathogenesis of allergic inflammation and asthma. Studies published in the Journal of Allergy and Clinical Immunology described advances in our knowledge of cells associated with allergic inflammation (mast cells, eosinophils, dendritic cells, and T cells), as well as IgE, cytokines, receptors, signaling molecules, and pathways. Studies used animal models, as well as human cells and tissues, to advance our understanding of mechanisms of asthma, eosinophilic esophagitis, food allergy, anaphylaxis and immediate hypersensitivity, mast cells and their disorders, atopic dermatitis, nasal polyposis, and hypereosinophilic syndromes. Additional studies provided novel information about the induction and regulation of allergic inflammation and the genetic contribution to allergic inflammation. Critical features of these studies and their potential effects on human atopic disorders are summarized here. (J Allergy Clin Immunol 2011;127:689-95.)