Gait variability magnitude but not structure is altered in essential tremor.
Gait variability magnitude but not structure is altered in essential tremor.
复制标题
特发性震颤中，步态变异程度发生改变，但结构并未发生改变。
DOI：
10.1016/j.jbiomech.2013.07.039
复制
发表时间：
2013
影响因子：
2.4
通讯作者：
Hass,ChrisJ
中科院分区：
文献类型：
--
作者：
Roemmich,RyanT;Zeilman,PamelaR;Vaillancourt,DavidE;Okun,MichaelS;Hass,ChrisJ
特发性震颤（ET）是一种常见的震颤障碍，影响上肢和中线的姿势/动作震颤。最近的研究表明，在串联步态的人与ET小脑一样的缺陷，虽然时空变异在正常步态的ET已相对被忽视。本研究的第一个目的是调查步态变异的幅度和结构在ET相比，健康的老年人（HOA）。为了解决这个问题，11 ET和11年龄匹配的HOA走在跑步机上5分钟，在首选的步行速度。HOA在与ET参与者速度匹配的情况下额外步行一分钟。第二个目的是描述该人群步态变异的临床相关性。为了实现这一目标，31名ET患者在跑步机上行走5分钟，并完成Fahn-Tolosa-Marin震颤评定量表。通过计算步长、步幅时间、步长、步长时间和步长宽度的变异系数，得出步态变异幅度。步态变异性结构，推导出使用去趋势波动分析技术。在首选的步行速度，ET参与者走得明显较慢，在所有五个时空步态参数的变异幅度显着增加。在速度匹配的步行，ET参与者表现出显着更高的步长变异性。组间步态变异性结构没有差异。我们还观察到，步态变异幅度预测上肢和中线震颤的严重程度。这项研究表明，自我选择的步态在ET的特点是高变异性，与震颤的严重程度在上肢和中线。
Essential tremor (ET) is a common tremor disorder affecting postural/action tremor of the upper extremities and midline. Recent research revealed a cerebellar-like deficit during tandem gait in persons with ET, though spatiotemporal variability during normal gait in ET has been relatively ignored. The first purpose of this study was to investigate gait variability magnitude and structure in ET as compared to healthy older adults (HOA). To address this issue, 11 ET and 11 age-matched HOAs walked on a treadmill for 5 min at preferred walking speeds. HOAs walked for an additional minute while speed-matched to an ET participant. The second purpose was to describe the clinical correlates of gait variability in this population. To address this aim, 31 persons with ET walked on a treadmill for 5 min and completed the Fahn–Tolosa–Marin Tremor Rating Scale. Gait variability magnitude was derived by calculating coefficients of variation in stride length, stride time, step length, step time, and step width. Gait variability structure was derived using a detrended fluctuation analysis technique. At preferred walking speeds, ET participants walked significantly slower with significantly increased variability magnitude in all five spatiotemporal gait parameters. At speed-matched walking, ET participants exhibited significantly higher step width variability. Gait variability structure was not different between groups. We also observed that gait variability magnitude was predicted by severity of upper extremity and midline tremors. This study revealed that self-selected gait in ET is characterized by high variability that is associated with tremor severity in the upper extremity and midline.