Correlations between behaviours in the elevated plus-maze and sensitivity to unpredictable subchronic mild stress: evidence from inbred strains of mice
Correlations between behaviours in the elevated plus-maze and sensitivity to unpredictable subchronic mild stress: evidence from inbred strains of mice
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DOI：
10.1016/j.bbr.2004.05.018
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发表时间：
2005-01-06
影响因子：
2.7
通讯作者：
Belzung, C
中科院分区：
文献类型：
--
作者：
Ducottet, C;Belzung, C
本研究旨在研究类焦虑和类抑郁行为在小鼠中的关系。因此，我们评估了来自8个不同品系(FVB/NA、BALB/c、C57BL/6、DBA/2、129/Sv、C3H/He、CBA和BA)的小鼠的行为，首先是面对焦虑模型(高架正迷宫和自由探索试验)，然后是抑郁样行为试验(强迫游泳试验和不可预测的亚慢性温和应激)。在强迫游泳实验中，DBA/2、BA和C3H/He品系的小鼠表现出比129/Sv、BALB/c、C57BL/6和CBA品系的小鼠更高的不动能。在亚慢性轻度应激中，C57BL/6和CBA品系的小鼠与其他品系的小鼠相比敏感性较低。逐步多元回归分析表明，在高架+迷宫中的行为与强迫游泳试验中的不动时间(20%)和对不可预测的亚慢性应激程序的易感性(31%)有关。自由探索性范式中的行为与两种抑郁症测试中的行为略有关联。这些结果表明，焦虑可能是导致抑郁样行为易感性的一个因素。(C)2004爱思唯尔B.V.保留所有权利。
This study aimed at investigating the relationship between anxiety-like and depressive-like behaviour in mice. Therefore, we assessed the behaviour of mice from eight different strains (FVB/NA, BALB/c, C57BL/6, DBA/2, 129/Sv, C3H/He, CBA and BA) confronted first to anxiety models (the elevated plus-maze and the free exploratory test) and then to tests of depressive-like behaviours (forced swim test and unpredictable subchronic mild stress). In the forced swim test, mice from the DBA/2, the BA and the C3H/He strains displayed higher immobility than mice from the 129/Sv, the BALB/c, the C57BL/6 and the CBA strains. In the subchronic mild stress, mice from the C57BL/6 and the CBA strains displayed low sensitivity when compared with mice from all the others strains. A stepwise multiple regression analysis suggests that behaviour in the elevated plus-maze is associated with the time of immobility in the forced swim test (20%) and with the susceptibility to the unpredictable subchronic stress procedure (31%). The behaviour in the free exploratory paradigm is slightly associated with behaviours in the two tests of depression. These results suggest that anxiety may be a factor contributing, among others, to the susceptibility to depressive-like behaviours. (C) 2004 Elsevier B.V. All rights reserved.