COLONIC FERMENTATION OF COMPLEX CARBOHYDRATES IN PATIENTS WITH FAMILIAL ADENOMATOUS POLYPOSIS
COLONIC FERMENTATION OF COMPLEX CARBOHYDRATES IN PATIENTS WITH FAMILIAL ADENOMATOUS POLYPOSIS
复制标题
DOI：
10.1136/gut.34.5.630
复制
发表时间：
1993-05-01
期刊：
影响因子：
24.5
通讯作者：
JOHNSTON, IDA
中科院分区：
文献类型：
--
作者：
BRADBURN, DM;MATHERS, JC;JOHNSTON, IDA
结肠碳水化合物发酵产生的丁酸减少可能导致结肠癌发生，隐含的假设是粪便丁酸的减少早于肿瘤的发展。研究了结肠肿瘤的遗传倾向和结肠息肉的存在对碳水化合物体外发酵的影响。将 11 名正常对照者和 20 名家族性腺瘤性息肉病 (FAP) 患者的粪便样本与一系列碳水化合物进行厌氧培养。葡萄糖和棉子糖的发酵模式相似。这些糖从淀粉和阿拉伯半乳聚糖这两种多糖中产生不同的短链脂肪酸（SCFA）模式，它们彼此不同。患有息肉的 FAP 基因携带者比正常对照产生更少的丁酸盐（p
Decreased production of butyric acid by colonic carbohydrate fermentation may predispose to colonic carcinogenesis, with the implicit assumption that the decrease in faecal butyrate found predates the development of the tumour. The influence of the genetic predisposition to colonic tumours and the presence of colonic polyps on in vitro fermentation of carbohydrates was examined. Stool samples from 11 normal controls and 20 patients with familial adenomatous polyposis (FAP) were incubated anaerobically with a range of carbohydrates. Fermentation patterns were similar for glucose and raffinose. These sugars produced different short chain fatty acid (SCFA) patterns from the two polysaccharides, starch and arabinogalactan, which differed one from the other. The FAP gene carriers with polyps produced less butyrate than normal controls (p