Intracellular correlates of fast (>200 Hz) electrical oscillations in rat somatosensory cortex
Intracellular correlates of fast (>200 Hz) electrical oscillations in rat somatosensory cortex
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DOI：
10.1152/jn.2000.84.3.1505
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发表时间：
2000-09-01
影响因子：
2.5
通讯作者：
Barth, DS
中科院分区：
文献类型：
--
作者：
Jones, MS;MacDonald, KD;Barth, DS
在人类和动物的体感诱发电位（SEP）中，已经观察到超过几百赫兹的振荡活动，并且越来越多地引起人们对其在脑功能中的作用的兴趣。然而，目前对这些振荡背后的细胞事件知之甚少。本研究采用细胞内和外皮场电位同步记录的方法，探讨了触须刺激引起的大鼠体感觉皮层快速振荡的细胞相关性。观察到两种不同类型的快速振荡，这里称为“快速振荡”（FO） （200-400 Hz）和“非常快速振荡”（VFO） （400-600 Hz）。FO与SEP最早的慢波分量重合，而VFO通常较晚，振幅较小。常规尖峰（RS）细胞表现出与一种或两种类型的快速振荡相关的触电诱发反应，并由尖峰和/或阈下事件的组合组成，当在多个试验中叠加时，这些事件聚集在由连续的FO或VFO活动周期或两者的组合分开的潜伏期。快速尖峰（FS）细胞对触须刺激产生的动作电位爆发反应与表面VFO的周期性非常接近。没有细胞以类似的方式产生与FO活动相关的动作电位爆发。我们提出，快速振荡定义了皮层RS细胞动作电位产生的首选潜伏期，抑制中间神经元产生的VFO和FO反映了皮层层中工作站的顺序和周期性活动。
Oscillatory activity in excess of several hundred hertz has been observed in somatosensory evoked potentials (SEP) recorded in both humans and animals and is attracting increasing interest regarding its role in brain function. Currently, however, little is known about the cellular events underlying these oscillations. The present study employed simultaneous in-vivo intracellular and epipial field-potential recording to investigate the cellular correlates of fast oscillations in rat somatosensory cortex evoked by vibrissa stimulation. Two distinct types of fast oscillations were observed, here termed "fast oscillations" (FO) (200-400 Hz) and "very fast oscillations" (VFO) (400-600 Hz). FO coincided with the earliest slow-wave components of the SEP whereas VFO typically were later and of smaller amplitude. Regular spiking (RS) cells exhibited vibrissa-evoked responses associated with one or both types of fast oscillations and consisted of combinations of spike and/or subthreshold events that, when superimposed across trials, clustered at latencies separated by successive cycles of FO or VFO activity, or a combination of both. Fast spiking (FS) cells responded to vibrissae stimulation with bursts of action potentials that closely approximated the periodicity of the surface VFO. No cells were encountered that produced action potential bursts related to FO activity in an analogous fashion. We propose that fast oscillations define preferred latencies for action potential generation in cortical RS cells, with VFO generated by inhibitory interneurons and FO reflecting both sequential and recurrent activity of stations in the cortical lamina.