Exploring the half-life of glyphosate in human urine samples
Exploring the half-life of glyphosate in human urine samples
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DOI：
10.1016/j.ijheh.2018.09.004
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发表时间：
2019-03-01
影响因子：
6
通讯作者：
Coggins, Marie A.
中科院分区：
文献类型：
--
作者：
Connolly, Alison;Jones, Kate;Coggins, Marie A.
背景：国际癌症研究机构 (IARC) 最近将草甘膦归类为 2A 类“可能对人类致癌”的物质。由于这种致癌分类和由此产生的国际争论，对评估草甘膦暴露对人类健康影响的研究的需求不断增加。目前关于人类接触草甘膦的信息有限，并且缺乏关于草甘膦在人体中的生物半衰期的数据。 目的：本研究旨在从使用草甘膦农药产品的市容园艺工人收集的人体尿液样本中估计草甘膦的人体半衰期。方法：在大约 24 小时内收集 8 次完全无效的尿液斑点样本。 工作任务涉及七名工人。使用三种不同的测量指标：未调整的草甘膦浓度、肌酐校正浓度以及使用尿排泄率 (UER)（μ g L-1、μ mol/mol 肌酐和 UER mu g L-1），通过回归分析的汇总和线性插值计算草甘膦的消除时间和半衰期估计。 结果：本研究估计了人体生物活性 对于未调整的样品、肌酐校正浓度和使用 UER（μ g L-1、pmol/mol 肌酐、UER mu g L-1），草甘膦的半衰期分别约为 5 1/2、10 和 7 1/4 小时。与其他测量指标相比，使用 UER 计算的草甘膦半衰期近似值似乎具有较小的变异性。 结论 这项研究提供了有关草甘膦消除率和人类生物半衰期近似范围的新信息。这些信息可以帮助优化采样策略的设计，并有助于解释涉及该活性成分的人类生物监测研究的结果。这些数据还有助于开发或完善草甘膦的生理药代动力学 (PBPK) 模型。
Background: The International Agency for Research on Cancer (IARC) has recently classified glyphosate as a Group 2A 'probably carcinogenic to humans'. Due to this carcinogenic classification and resulting international debate, there is an increased demand for studies evaluating human health effects from glyphosate exposures. There is currently limited information on human exposures to glyphosate and a paucity of data regarding glyphosate's biological half-life in humans.Objective: This study aims to estimate the human half-life of glyphosate from human urine samples collected from amenity horticulture workers using glyphosate based pesticide products.Methods: Full void urine spot samples were collected over a period of approximately 24 h for eight work tasks involving seven workers. The elimination time and estimation of the half-life of glyphosate using three different measurement metrics: the unadjusted glyphosate concentrations, creatinine corrected concentrations and by using Urinary Excretion Rates (UER) (mu g L-1, mu mol/mol creatinine and UER mu g L-1) was calculated by summary and linear interpolation using regression analysis.Results: This study estimates the human biological half-life of glyphosate as approximately 5 1/2, 10 and 7 1/4 hours for unadjusted samples, creatinine corrected concentrations and by using UER (mu g L-1, pmol/mol creatinine, UER mu g L-1), respectively. The approximated glyphosate half-life calculations seem to have less variability when using the UER compared to the other measuring metrics.Conclusion This study provides new information on the elimination rate of glyphosate and an approximate biological half-life range for humans. This information can help optimise the design of sampling strategies, as well as assisting in the interpretation of results for human biomonitoring studies involving this active ingredient. The data could also contribute to the development or refinement of Physiologically Based PharmacoKinetic (PBPK) models for glyphosate.