Sleep deprivation and adrenalectomy lead to enhanced innate escape response to visual looming stimuli
Sleep deprivation and adrenalectomy lead to enhanced innate escape response to visual looming stimuli
复制标题
睡眠剥夺和肾上腺切除术导致对迫在眉睫的视觉刺激的先天逃避反应增强
DOI：
10.1016/j.bbrc.2020.04.061
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发表时间：
2020
影响因子：
3.1
通讯作者：
Wang Liping
中科院分区：
文献类型：
--
作者：
Tseng Yu-Ting;Zhao Binghao;Liu Jingjing;Ding Hui;Wang Feng;Wang Liping
使动物能够适应特定条件的先天行为的最佳选择，无论是环境还是内部，仍然知之甚少。我们报告说，小鼠急性（8小时）睡眠剥夺有一个增强的先天逃避反应和上调c-fos表达在多个大脑区域，调节觉醒。相比之下，在同样的睡眠剥夺条件下，肾上腺切除的小鼠表现出更夸张的逃避反应，这些调节唤醒的大脑区域更加活跃。这表明，急性睡眠剥夺增强了先天逃避反应，可能是通过改变清醒状态而不会引起显著的焦虑。我们还报告说，下丘脑-垂体-肾上腺轴反馈睡眠剥夺下防止夸张的逃避反应，通过调节唤醒调节脑区。总的来说，我们的研究结果表明，动物优先考虑逃避反应而不是睡眠，因为这两种行为的需求同时增加。我们还提供了一个深入了解睡眠和先天逃避反应之间的相互作用的神经机制。
Optimal selections of innate behaviors that enable animals to adapt to particular conditions, whether environmental or internal, remain poorly understood. We report that mice under acute (8 h) sleep deprivation had an enhanced innate escape response and upregulation of c-fos expression in multiple brain areas that regulate wakefulness. By comparison, adrenalectomized mice under the same sleep deprivation condition displayed an even more exaggerated escape response and these wake-regulating brain areas were even more active. This suggests that acute sleep deprivation enhances innate escape response, possibly by altering wake state without causing significant anxiety. We also report that the hypothalamic–pituitary–adrenal axis feedback under sleep deprivation prevents an exaggerated escape response by modulating wake-regulating brain areas. Taken together, our findings suggest that animals prioritize escape response over sleep, as the need of both behaviors simultaneously increase. We also provide an insight into the neural mechanisms underlying the interaction between sleep and innate escape response.