Multiple Somatotopic Representations of Heat and Mechanical Pain in the Operculo-Insular Cortex: A High-Resolution fMRI Study
Multiple Somatotopic Representations of Heat and Mechanical Pain in the Operculo-Insular Cortex: A High-Resolution fMRI Study
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DOI：
10.1152/jn.00253.2010
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发表时间：
2010-11-01
影响因子：
2.5
通讯作者：
Tracey, Irene
中科院分区：
文献类型：
--
作者：
Baumgaertner, Ulf;Iannetti, Gian Domenico;Tracey, Irene
鲍姆加特纳U，Iannetti GD，Zambreanu L，Stoeter P，Treeed Rd，Tracey I.多个体位表现的岛叶外皮质热和机械性疼痛：一项高分辨率功能磁共振研究。神经生理学杂志104：2863-2872,2010。2010年8月25日首次出版；DOI：10.1152/jn.00253.2010。虽然触觉的体感表征研究有助于区分初级(SI)和次级(SII)躯体感觉皮层区域内的多个躯体感觉区域，但对于跨伤害性感觉方式的疼痛表征还没有这样的分析。本文应用高分辨率(2×2×4 mm)3T功能磁共振成像(FMRI)研究了11名健康受试者在伤害性高温和针刺刺激下岛叶盖皮质的体视功能。热刺激(使用激光)和针刺刺激(使用点状探头)以平衡的设计被引导到右手和脚的背部。比较刺激部位(手和脚)和刺激方式(热刺激和针刺刺激)在四个感兴趣的双侧脑岛前部和后部以及额盖部和顶盖部的fMRI峰值位置。重要的是，所有的分析都是在单独的、非标准化的fMRI图像上进行的。对于热刺激，我们在对侧的前岛和后岛[手，足前9+/-10(SD，P<；0.05)]和对侧的顶盖(手，脚外7+/-10 mm，P<；0.05)发现手足体位。对于针刺刺激，我们还发现对侧后岛(手，足前9+/-10 mm，P<；0.05)存在体位。此外，手对热刺激的反应比对侧(左侧)前岛针刺手的反应早11+/-12 mm(P<；0.05)。这些结果表明，在人类岛盖区域内存在对疼痛的多个躯体视觉表征，这可能反映了其作为感觉整合部位的重要性，该部位根据受伤的身体部位适当地指导情绪反应和行为。
Baumgartner U, Iannetti GD, Zambreanu L, Stoeter P, Treede RD, Tracey I. Multiple somatotopic representations of heat and mechanical pain in the operculo-insular cortex: a high-resolution fMRI study. J Neurophysiol 104: 2863-2872, 2010. First published August 25, 2010; doi:10.1152/jn.00253.2010. Whereas studies of somatotopic representation of touch have been useful to distinguish multiple somatosensory areas within primary (SI) and secondary (SII) somatosensory cortex regions, no such analysis exists for the representation of pain across nociceptive modalities. Here we investigated somatotopy in the operculo-insular cortex with noxious heat and pinprick stimuli in 11 healthy subjects using high-resolution (2 X 2 X 4 mm) 3T functional magnetic resonance imaging (fMRI). Heat stimuli (delivered using a laser) and pinprick stimuli (delivered using a punctate probe) were directed to the dorsum of the right hand and foot in a balanced design. Locations of the peak fMRI responses were compared between stimulation sites (hand vs. foot) and modalities (heat vs. pinprick) within four bilateral regions of interest: anterior and posterior insula and frontal and parietal operculum. Importantly, all analyses were performed on individual, non-normalized fMRI images. For heat stimuli, we found hand-foot somatotopy in the contralateral anterior and posterior insula [hand, 9 +/- 10 (SD) mm anterior to foot, P < 0.05] and in the contralateral parietal operculum (SII; hand, 7 +/- 10 mm lateral to foot, P < 0.05). For pinprick stimuli, we also found somatotopy in the contralateral posterior insula (hand, 9 +/- 10 mm anterior to foot, P < 0.05). Furthermore, the response to heat stimulation of the hand was 11 +/- 12 mm anterior to the response to pinprick stimulation of the hand in the contralateral (left) anterior insula (P < 0.05). These results indicate the existence of multiple somatotopic representations for pain within the operculo-insular region in humans, possibly reflecting its importance as a sensory-integration site that directs emotional responses and behavior appropriately depending on the body site being injured.