Utility of the Addenbrooke's Cognitive Examination - Revised for the diagnosis of dementia syndromes
Utility of the Addenbrooke's Cognitive Examination - Revised for the diagnosis of dementia syndromes
复制标题
DOI：
10.1111/j.1741-6612.2010.00446.x
复制
发表时间：
2011-09-01
影响因子：
1.6
通讯作者：
Lindley, Richard I.
中科院分区：
文献类型：
--
作者：
Terpening, Zoe;Cordato, Nicholas J.;Lindley, Richard I.
目的：评价阿登布鲁克认知检查-修订（ACE-R）作为痴呆筛查工具的效用。方法：前瞻性审计122例患者（82例痴呆，40例无痴呆）转到悉尼认知诊所。结果：ACE-R的临界值为84/100，在识别痴呆患者时提供了敏感性、特异性和阳性预测值（分别为0.85、0.80和0.90）的最佳平衡。在我们的样本中，ACE-R在受教育程度较高的患者（>= 10年正规学校教育）中是优于简易精神状态检查的痴呆症筛查工具，但在受教育程度较低的患者中则不是。被仪器错误分类的患者有高教育水平、局灶性执行功能障碍、医疗合并症、重大血管疾病和多种药理的证据。结论：ACE-R是一种有用的筛查工具，用于检测认知临床设置痴呆的存在。在某些患者群体中谨慎是有必要的。
Aim: To evaluate the utility of the Addenbrooke's Cognitive Examination - Revised (ACE-R) as a screening tool for dementia.Method: Prospective audit of 122 patients (82 with dementia, 40 with no dementia) referred to a Sydney cognition clinic.Results: An ACE-R cut-off score of 84/100 provided an optimal balance of sensitivity, specificity and positive predictive value (0.85, 0.80 and 0.90, respectively) in identifying patients with dementia. In our sample, the ACE-R was a superior dementia screening tool to the Mini-Mental State Examination in patients with higher levels of education (>= 10 years of formal schooling), but not in patients with lower levels of education. Patients misclassified by the instrument had evidence of high levels of education, focal executive dysfunction, medical comorbidities, significant vascular disease and polypharmacology.Conclusions: The ACE-R is a useful screening tool for detecting the presence of dementia in a cognition clinic setting. Caution may be warranted in some patient populations.