Fungal Melanin: What do We Know About Structure?
Fungal Melanin: What do We Know About Structure?
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DOI：
10.3389/fmicb.2015.01463
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发表时间：
2015
影响因子：
5.2
通讯作者：
Casadevall A
中科院分区：
文献类型：
--
作者：
Nosanchuk JD;Stark RE;Casadevall A
黑色素的产生显著增强了许多重要的人类病原真菌的毒力。尽管真菌黑色素在人类疾病中的重要性，以及黑色素对真菌在不同恶劣环境中生存能力的贡献，黑色素的结构仍然没有解决。然而，正在进行的研究工作逐渐揭示了这种神秘色素的几个显著的结构特征，这将是本综述的重点。这些成分和组织上的见解可以进一步提高我们开发抗击真菌疾病的新治疗方法的能力，并增强我们对黑色素是如何插入细胞壁的理解。
The production of melanin significantly enhances the virulence of many important human pathogenic fungi. Despite fungal melanin’s importance in human disease, as well as melanin’s contribution to the ability of fungi to survive in diverse hostile environments, the structure of melanin remains unsolved. Nevertheless, ongoing research efforts have progressively revealed several notable structural characteristics of this enigmatic pigment, which will be the focus of this review. These compositional and organizational insights could further our ability to develop novel therapeutic approaches to combat fungal disease and enhance our understanding of how melanin is inserted into the cell wall.