TRANS-ACTING TRANSCRIPTIONAL REGULATION OF HUMAN T-CELL LEUKEMIA-VIRUS TYPE-III LONG TERMINAL REPEAT
TRANS-ACTING TRANSCRIPTIONAL REGULATION OF HUMAN T-CELL LEUKEMIA-VIRUS TYPE-III LONG TERMINAL REPEAT
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DOI：
10.1126/science.2981427
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
HASELTINE, WA
中科院分区：
文献类型：
--
作者：
SODROSKI, J;ROSEN, C;HASELTINE, WA
人类T细胞白血病病毒Ⅲ型（HTLV-Ⅲ）是近年来发现的一种可能的获得性免疫缺陷综合征（AIDS）病原体。在感染HTLV-III的人T细胞系中，与匹配的未感染细胞相比，由该病毒的长末端重复序列指导的基因表达被刺激> 2个数量级。在1个感染细胞系中，HTLV-III长末端重复序列的转录速率是SV 40早期启动子的1000倍以上。HTLV-III与HTLV-I、HTLV-II和牛白血病病毒一样，其特征在于感染细胞中转录的反式激活。在HTLV-III的情况下，反式激活的效率可以至少部分地解释HTLV-III感染的毒性性质。
Human T-cell leukemia virus type III (HTLV-III) was recently identified as the probable etiologic agent of the acquired immune deficiency syndrome (AIDS). In human T-cell lines infected with HTLV-III, gene expression directed by the long terminal repeat sequence of this virus is stimulated by > 2 orders of magnitude compared to matched uninfected cells. The rate of transcription of the HTLV-III long terminal repeat is more than 1000 times that of the SV40 early promoter in 1 infected cell line. HTLV-III, like HTLV-I, HTLV-II, and the bovine leukemia virus, is characterized by trans-activation of transcription in infected cells. The efficiency of trans-activation in the case of HTLV-III may account, at least in part, for the virulent nature of HTLV-III infection.