Impact of Senolytic Treatment on Gene Expression in Aged Lung.
Impact of Senolytic Treatment on Gene Expression in Aged Lung.
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DOI：
10.3390/ijms24087628
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发表时间：
2023-04-21
影响因子：
5.6
通讯作者：
Stout-Delgado, Heather
中科院分区：
文献类型：
--
作者：
Cho, Soo Jung;Pronko, Alexander;Yang, Jianjun;Stout-Delgado, Heather
细胞衰老在介导组织重塑和调节宿主对病原刺激的反应中起关键作用。我们目前的研究旨在更好地了解短期衰老治疗或炎症刺激对肺衰老的影响。我们的研究结果表明，短期治疗老年成年小鼠（20个月大）与senolytics，槲皮素，和达沙替尼降低肺组织中的p16和p21表达。用senolytics短期治疗还显著改善了与基因组不稳定性、端粒磨损、线粒体功能障碍、DNA结合和炎症反应相关的基因的表达。相比之下，响应于低剂量LPS施用，在年轻成年小鼠肺（3月龄）中与基因组不稳定性、线粒体功能障碍和升高的炎症反应相关的基因表达增加。总之，我们目前研究的结果说明了衰老清除治疗对调节老年肺中的反应的功效以及慢性低剂量炎症对肺中衰老诱导的潜在作用。
Cellular senescence plays a key role in mediating tissue remodeling and modulation of host responses to pathogenic stimuli. Our current study was designed to gain a better understanding of the impact of short-term senolytic treatment or inflammatory stimulation on lung senescence. The results of our study demonstrate that short term treatment of aged adult mice (20 months of age) with senolytics, quercetin, and dasatinib decreases p16 and p21 expression in lung tissue. Short-term treatment with senolytics also significantly improved the expression of genes associated with genomic instability, telomere attrition, mitochondrial dysfunction, DNA binding, and the inflammatory response. In contrast, in response to low-dose LPS administration, there was increased expression of genes associated with genomic instability, mitochondrial dysfunction, and heightened inflammatory responses in young adult murine lung (3 months of age). Taken together, the results of our current study illustrate the efficacy of senolytic treatment on modulating responses in aged lung and the potential role of chronic low dose inflammation on senescence induction in the lung.
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影响因子：
8
作者：
Bikkavilli RK;Avasarala S;Van Scoyk M;Arcaroli J;Brzezinski C;Zhang W;Edwards MG;Rathinam MK;Zhou T;Tauler J;Borowicz S;Lussier YA;Parr BA;Cool CD;Winn RA
通讯作者：
Winn RA
影响因子：
82.9
作者：
Liu, BH;Wang, JM;Zhou, ZJ
通讯作者：
Zhou, ZJ
槲皮素通过调节氧化低密度脂蛋白诱导的内皮细胞衰老减轻动脉粥样硬化
影响因子：
5.6
作者：
Jiang, Yue-Hua;Jiang, Ling-Yu;Li, Xiao
通讯作者：
Li, Xiao
影响因子：
11.1
作者：
Hickson, LaTonya J.;Prata, Larissa G. P. Langhi;Kirkland, James L.
通讯作者：
Kirkland, James L.
影响因子：
15.9
作者：
McQuattie-Pimentel, Alexandra C.;Ren, Ziyou;Budinger, G. R. Scott
通讯作者：
Budinger, G. R. Scott