NEW METHOD FOR MEASURING AIRWAY RESISTANCE IN MAN USING A BODY PLETHYSMOGRAPH - VALUES IN NORMAL SUBJECTS AND IN PATIENTS WITH RESPIRATORY DISEASE
NEW METHOD FOR MEASURING AIRWAY RESISTANCE IN MAN USING A BODY PLETHYSMOGRAPH - VALUES IN NORMAL SUBJECTS AND IN PATIENTS WITH RESPIRATORY DISEASE
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DOI：
10.1172/jci103282
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发表时间：
1956-01-01
影响因子：
15.9
通讯作者：
COMROE, JH
中科院分区：
文献类型：
--
作者：
DUBOIS, AB;BOTELHO, SY;COMROE, JH
本文报道了一种客观、特异地测量人体呼吸道阻力的新方法。它需要测量气流和气流过程中的肺泡压力。肺泡压力是通过利用人体体积描记器测定呼气和吸气时肺泡气体的压缩和减压体积来测量的。用该方法测得正常人的平均气道阻力为1.5cmH2O/L/秒(范围0.6-2.4)，流速为1I/秒时，出现喘息。本文对30例患者的气道阻力进行了初步研究，阻力范围为0.6~10.8cmH2O/L/秒。这种方法被认为适用于测量患者的气道阻力，评估旨在缓解气道阻塞的治疗程序，分离气道阻力和组织阻力，以及研究可能影响气道阻力的多种因素。
A new method is reported for the objective and specific measurement of airway resistance in human subjects. It requires the measurement of airflow and of alveolar pressure during airflow. The alveolar pressure is measured by determining, by means of a body plethysmograph, the volume of compression and decompression of alveolar gas during expiration and inspiration. Normal subjects tested by this method had a mean airway resistance of 1.5 cm H2O/l/second (range 0.6 - 2.4) at a flow rate of 1 I/second, panting. A preliminary study was made of the airway resistance in 30 patients; the range of resistances was 0.6 - 10.8 cm H2O/l/second. This method is thought to be applicable to measurement of airway resistance in patients, evaluation of therapeutic procedures designed to relieve airway obstruction, separation of airway resistance from tissue resistance, and study of multiple factors that may affect airway resistance.