Epithelial-myoepithelial carcinoma of the lung: Immunohistochemical and ultrastructural observations and review of the literature
Epithelial-myoepithelial carcinoma of the lung: Immunohistochemical and ultrastructural observations and review of the literature
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DOI：
10.1016/s0046-8177(97)90088-5
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发表时间：
1997-05-01
期刊：
影响因子：
3.3
通讯作者：
Moran, CA
中科院分区：
文献类型：
--
作者：
Wilson, RW;Moran, CA
Epithelial-myoepithelial carcinoma is a rare lo iv-grade malignant salivary gland neoplasm that most commonly occurs in the parotid gland but can also arise in minor salivary glands. We report a case of a primary epithelial-myoepithelial carcinoma of the lung, The patient is a 55-year-old black woman who presented with increasing shortness of breath and productive cough of at least 3 months duration, A left lower lobe endobronchial lesion was identified radiographically, Surgical resection of the lesion was performed, obtaining a circumscribed, nonencapsulated 3.9 cm tan mass which was attached to the inner wall of the lateral basal segment bronchus, A biphasic proliferation of epithelial (cytokeratin positive; S-100 protein and muscle-specific actin negative) and myoepithelial (S-100 protein and muscle-specific actin positive with focal weak cytokeratin positive) cells was identified by immunohistochemical and ultrastructural analysis of formalin-fixed tissue, The patient is disease free 7 months after resection, Pulmonary epithelial-myoepithelial carcinoma likely derives from the submucosal bronchial glands and should be added to the growing list of salivary gland-type neoplasms that may occur as primary pulmonary neoplasms, Because its histology is identical to salivary epithelial-myoepithelial carcinoma, pulmonary epithelial-myoepithelial carcinoma should be considered a low-grade malignant neoplasm and should be designated as epithelial-myoepithelial carcinoma in preference to other terms that may not convey its malignant potential, Although follow-up on reported cases is limited, lobectomy with negative bronchial margin should be curative.
