The role and regulation of human Th17 cells in tumor immunity.
The role and regulation of human Th17 cells in tumor immunity.
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DOI：
10.1016/j.ajpath.2012.08.041
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Jian Ye;Robert S. Livergood;Guangyong Peng
中科院分区：
文献类型：
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作者：
Jian Ye;Robert S. Livergood;Guangyong Peng
辅助性T细胞17（Th17）在炎症和自身免疫性疾病的发病机制中以及在宿主抵抗病原体的保护中起关键作用。然而，Th17细胞对人类肿瘤免疫的贡献在很大程度上仍然未知。自2005年发现以来，Th17细胞已在小鼠肿瘤模型和人类癌症患者中得到广泛研究。虽然越来越多的数据表明Th17细胞对肿瘤免疫的重要性，但关于Th17细胞功能作用的结论仍然存在争议。在这篇综述中，我们总结了目前的知识有关的调节和功能作用的Th17细胞在人类癌症。特别是，我们强调几个最近确定的特性，Th17细胞，包括可塑性，它们与调节性T细胞的关系，和Th17细胞在肿瘤微环境中的异质性。对这些问题的进一步理解对于阐明Th17细胞在抗肿瘤免疫中的作用以及设计特异性靶向Th17细胞的新型治疗方法至关重要。
T helper 17 (Th17) cells play critical roles in the pathogenesis of inflammatory and autoimmune diseases, as well as in host protection against pathogens. The contribution of Th17 cells to human tumor immunity, however, remains largely unknown. Since their identification in 2005, Th17 cells have been extensively studied in mouse tumor models and human cancer patients. Although accumulating data suggest the importance of Th17 cells to tumor immunity, conclusions regarding the functional role of Th17 cells remain controversial. In this review, we summarize current knowledge regarding the regulation and functional role of Th17 cells in human cancers. In particular, we emphasize several recently identified characteristics of Th17 cells, including plasticity, their relationship with regulatory T cells, and Th17 cell heterogeneity in the tumor microenvironment. Improved understanding of these issues is critical to elucidating the role of Th17 cells in antitumor immunity and for the design of novel therapeutic approaches specifically targeting Th17 cells.