Utility of video capsule endoscopy for longitudinal monitoring of Crohn's disease activity in the small bowel: a prospective study
Utility of video capsule endoscopy for longitudinal monitoring of Crohn's disease activity in the small bowel: a prospective study
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DOI：
10.1016/j.gie.2018.07.035
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发表时间：
2018-12-01
影响因子：
7.7
通讯作者：
Leighton, Jonathan A.
中科院分区：
文献类型：
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作者：
Melmed, Gil Y.;Dubinsky, Marla C.;Leighton, Jonathan A.
背景和目标：本前瞻性多中心研究评价小肠胶囊式内窥镜（CE）用于克罗恩病（CD）受试者粘膜炎症的纵向评估。方法：已知CD受试者在基线和6个月随访时接受回结肠镜检查和CE的临床评价。在两个时间点的CE检查前确认小肠通畅。回结肠镜检查采用CD简易内镜评分（SES-CD），CE检查采用刘易斯评分和CE CD内镜严重程度指数（CECDEIS）。临床评分指数包括医师总体评估（PGA）、CD活动指数（CDAI）和Harvey-Bradshaw指数（HBI）。在基线和随访时收集实验室标志物，包括C反应蛋白、粪便钙卫蛋白和红细胞沉降率。内镜评分和临床参数之间的相关性进行了测量，使用斯皮尔曼tests.Results：共74名受试者参加，其中53人（72%）完成内镜手术在基线和6个月的后续行动。回结肠镜SES-CD评分与刘易斯评分相关（P
Background and Aims: This prospective, multicenter study evaluated small-bowel capsule endoscopy (CE) for the longitudinal assessment of mucosal inflammation in subjects with Crohn's disease (CD).Methods: Subjects with known CD underwent clinical evaluation with ileocolonoscopy and CE at baseline and 6-month follow-up. Small-bowel patency was confirmed before CE at both time points. The Simple Endoscopic Score for CD (SES-CD) was used for ileocolonoscopy, and the Lewis score and the CE CD Endoscopic Index of Severity (CECDEIS) were used for CE. Clinical scoring indices included the Physician Global Assessment (PGA), CD Activity Index (CDAI), and Harvey-Bradshaw Index (HBI). Laboratory markers including C-reactive protein, fecal calprotectin, and erythrocyte sedimentation rate were collected at baseline and follow-up. Correlation between endoscopic scores and clinical parameters were measured using Spearman tests.Results: A total of 74 subjects were enrolled, of whom 53 (72%) completed endoscopic procedures at baseline and 6-month follow-up. The SES-CD ileocolonoscopy score correlated with the Lewis score (P