Circulating and intraprostatic sex steroid hormonal profiles in relation to male pattern baldness and chest hair density among men diagnosed with localized prostate cancers.
Circulating and intraprostatic sex steroid hormonal profiles in relation to male pattern baldness and chest hair density among men diagnosed with localized prostate cancers.
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循环和前列腺内性类固醇激素分布与诊断患有局限性前列腺癌的男性的男性型秃发和胸毛密度有关。
DOI：
10.1002/pros.23433
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Levine,Pau
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作者：
Zhou,CindyKe;Stanczyk,FrankZ;Hafi,Muhannad;Veneroso,CarmelaC;Lynch,Barlow;Falk,RoniT;Niwa,Shelley;Emanuel,Eric;Gao,Yu-Tang;Hemstreet,GeorgeP;Zolfghari,Ladan;Carroll,PeterR;Manyak,MichaelJ;Sesterhenn,IsabellA;Levine,Pau
尽管有动物和临床研究的证据，但关于循环性类固醇激素和前列腺癌风险的前瞻性队列研究并没有提供一致的相关性。然而，使用男性型秃发作为早期或累积雄激素暴露的代表的研究报告了与侵袭性和致命性前列腺癌风险的显著相关性。鉴于雄激素的发展模式的脱发和胸毛的基础，我们评估这两个皮肤病学特征是否与循环和intraprostate浓度的性类固醇激素诊断为局限性前列腺癌的男性。MethodsWe包括248例前列腺癌患者从NCI前列腺组织研究，他们回答了调查，并提供了治疗前的血液样本以及新鲜冷冻的相邻正常前列腺组织。男性型秃发和胸毛密度由训练有素的护士术前评估。一般线性模型通过皮肤表型估计每个激素变量的几何平均值和95%置信区间（95%CI），并调整潜在的混杂变量。通过Gleason评分（<7 vs ≥7）和种族（欧洲裔美国人vs.非洲裔美国人）进行亚组分析。结果我们发现秃顶状态与血清睾酮、双氢睾酮（DHT）、雌二醇和性激素结合球蛋白（SHBG）有很强的正相关性，与前列腺内睾酮升高有弱相关性。相反，无论是循环还是前列腺内的性激素与胸毛密度都没有统计学意义。年龄调整后的二元秃顶状态和三级胸毛密度之间的相关性较弱（r= 0.05）。几乎没有证据表明，格里森评分或种族修改这些association.ConclusionsThis研究提供的证据表明，秃头状态评估的平均年龄为60岁，可作为一个临床标志物循环性激素浓度。秃头状态和前列腺内性激素之间的弱至零关联重申了器官特异性激素代谢的差异，这意味着其他性类固醇激素相关因子（例如，雄激素受体）在器官特异性雄激素作用中发挥重要作用，并且其他重叠途径可能涉及两种复杂条件之间的关联。
BackgroundProspective cohort studies of circulating sex steroid hormones and prostate cancer risk have not provided a consistent association, despite evidence from animal and clinical studies. However, studies using male pattern baldness as a proxy of early‐life or cumulative androgen exposure have reported significant associations with aggressive and fatal prostate cancer risk. Given that androgens underlie the development of patterned hair loss and chest hair, we assessed whether these two dermatological characteristics were associated with circulating and intraprostatic concentrations of sex steroid hormones among men diagnosed with localized prostate cancer.MethodsWe included 248 prostate cancer patients from the NCI Prostate Tissue Study, who answered surveys and provided a pre‐treatment blood sample as well as fresh frozen adjacent normal prostate tissue. Male pattern baldness and chest hair density were assessed by trained nurses before surgery. General linear models estimated geometric means and 95% confidence intervals (95%CIs) of each hormone variable by dermatological phenotype with adjustment for potential confounding variables. Subgroup analyses were performed by Gleason score (<7 vs ≥7) and race (European American vs. African American).ResultsWe found strong positive associations of balding status with serum testosterone, dihydrotestosterone (DHT), estradiol, and sex hormone‐binding globulin (SHBG), and a weak association with elevated intraprostatic testosterone. Conversely, neither circulating nor intraprostatic sex hormones were statistically significantly associated with chest hair density. Age‐adjusted correlation between binary balding status and three‐level chest hair density was weak (r= 0.05). There was little evidence to suggest that Gleason score or race modified these associations.ConclusionsThis study provides evidence that balding status assessed at a mean age of 60 years may serve as a clinical marker for circulating sex hormone concentrations. The weak‐to‐null associations between balding status and intraprostatic sex hormones reaffirm differences in organ‐specific sex hormone metabolism, implying that other sex steroid hormone‐related factors (eg, androgen receptor) play important roles in organ‐specific androgenic actions, and that other overlapping pathways may be involved in associations between the two complex conditions.