Deletion of the side chain assembly reveals diverse post-PKS modifications in the biosynthesis of ansatrienins
Deletion of the side chain assembly reveals diverse post-PKS modifications in the biosynthesis of ansatrienins
复制标题
侧链组装的删除揭示了 ansatrienins 生物合成中的多种 PKS 后修饰
DOI：
10.1039/c6ra19036g
复制
发表时间：
2016-01-01
期刊：
影响因子：
3.9
通讯作者：
Shen, Yuemao
中科院分区：
文献类型：
--
作者：
Li, Xiaomei;Zhu, Jing;Shen, Yuemao
从链霉菌XZQH 13 OE Δ astC中分离到7个新的安莎三烯素型安莎霉素，即安莎三烯醇B-H（1-7），沿着4个已知的安莎三烯醇（8-11）。通过1D和2D NMR光谱数据和高分辨率ESIMS分析确定了它们的结构。本研究揭示了ansatrienins生物合成过程中不同的PKS后修饰。
Seven new ansatrienin-type ansamycins, namely, ansatrienols B-H (1-7), along with four known ones (8-11), were isolated from the strain Streptomyces sp. XZQH13OE Delta astC constructed by deleting the astC gene responsible for the assembly of the N-cyclohexanoyl D-alanyl side chain. Their structures were determined by analysis of the 1D and 2D NMR spectroscopic data and high-resolution ESIMS. This study revealed the diverse post-PKS modifications during the biosynthesis of ansatrienins.