Association of a mast cell chymase gene variant with HDL cholesterol, but not with blood pressure in the Ohasama study
Association of a mast cell chymase gene variant with HDL cholesterol, but not with blood pressure in the Ohasama study
复制标题
DOI：
10.1291/hypres.25.179
复制
发表时间：
2002-03-01
影响因子：
5.4
通讯作者：
Ogihara, T
中科院分区：
文献类型：
--
作者：
Fukuda, M;Ohkubo, T;Ogihara, T
两种酶，糜酶和血管紧张素转换酶（ACE），参与血管紧张素II的生产。我们以前的研究揭示了ACE DD基因型对高血压风险的男性特异性影响，但糜酶的遗传作用仍不清楚。在本研究中，我们报告了一项关联研究的结果，该研究涉及从日本北方农村社区Ohasama的普通人群中招募的1，046名受试者。除了偶然的血压（偶然的血压）测量，家庭血压测量从所有参与者。根据肥大细胞糜酶基因（MCC）的G3255A多态性，家庭或临时BP值没有差异。HDL胆固醇水平在A3255等位基因携带者中显著较高（p
Two enzymes, chymase and angiotensin converting enzyme (ACE), are involved in the production of anglotensin II. Our previous study revealed the male-specific effect of the ACE DD genotype on the risk for hypertension, but the genetic role of chymase remains unclear. In the present study, we report the results of an association study involving 1,046 subjects recruited from a general population in Ohasama, a rural community In the northern part of Japan. In addition to casual blood pressure (casual BP) measurement, home BP measurements were obtained from all participants. There were no differences in either home or casual BP values according to G3255A polymorphism of the mast cell chymase gene (MCC). HDL cholesterol level was significantly higher among carriers of the A3255 allele (p