C-reactive protein elevation in patients with atrial arrhythmias - Inflammatory mechanisms and persistence of atrial fibrillation
C-reactive protein elevation in patients with atrial arrhythmias - Inflammatory mechanisms and persistence of atrial fibrillation
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DOI：
10.1161/hc4901.101760
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发表时间：
2001-12-11
期刊：
影响因子：
37.8
通讯作者：
Van Wagoner, DR
中科院分区：
文献类型：
--
作者：
Chung, MK;Martin, DO;Van Wagoner, DR
背景-由于炎症促进了心房结构的改变，房颤(AF)可能会持续存在。C反应蛋白(CRP)是全身炎症的标志，可以预测心血管事件和中风，这是房颤的常见后遗症。我们推测，房性心律失常患者的CRP水平升高。方法和结果：采用病例对照研究设计，将131例房性心律失常患者的CRP与71例对照组的CRP进行比较。心律失常患者中，6例为房性异位或心动过速，86例为阵发性房颤，39例为持续性房颤，70例为孤立性心律失常。心律失常组C反应蛋白水平高于对照组(中位数分别为0.21和0.096 mg/dL；P
Background-Atrial Fibrillation (AF) may persist due to structural changes in the atria that are promoted by inflammation. C-reactive protein (CRP), a marker of systemic inflammation, predicts cardiovascular events and stroke, a common sequela of AF. We hypothesized that CRP is elevated in patients, with atrial arrhythmias. Methods and Results-Using a case-control study design, CRP in 131 patients with atrial arrhythmias was compared with CRP in 71 control patients. Among arrhythmia patients, 6 had frequent atrial ectopy or tachycardia, 86 had paroxysmal AF, 39 had persistent AF lasting > 30 days, and 70 had lone arrhythmias. CRP was higher in arrhythmia than in control patients (median, 0.21 versus 0.096 mg/dL; P