Vigorous HIV-1-specific CD4(+) T cell responses associated with control of viremia
Vigorous HIV-1-specific CD4(+) T cell responses associated with control of viremia
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DOI：
10.1126/science.278.5342.1447
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发表时间：
1997-11-21
期刊：
影响因子：
56.9
通讯作者：
Walker, BD
中科院分区：
文献类型：
--
作者：
Rosenberg, ES;Billingsley, JM;Walker, BD
在许多慢性病毒感染中，病毒特异性的CD4(+)T辅助淋巴细胞对维持有效免疫至关重要，但在慢性人类免疫缺陷病毒1型(HIV-1)感染中却典型地检测不到。在没有抗病毒治疗的情况下控制病毒血症的人，出现了多克隆的、持续的和强烈的HIV-1特异性CD4(+)T细胞增殖反应，导致干扰素-伽马和抗病毒β趋化因子的产生。在慢性感染者中，HIV-1对p24的特异性增殖反应与病毒载量呈负相关。在对急性感染者进行有效的抗病毒治疗后，也检测到强烈的HIV-1特异性增殖反应。HIV-1特异性辅助细胞可能在免疫治疗干预和疫苗开发中发挥重要作用。
Virus-specific CD4(+) T helper lymphocytes are critical to the maintenance of effective immunity in a number of chronic viral infections, but are characteristically undetectable in chronic human immunodeficiency virus-type 1 (HIV-1) infection. In individuals who control viremia in the absence of antiviral therapy, polyclonal, persistent, and vigorous HIV-1-specific CD4(+) T cell proliferative responses were present, resulting in the elaboration of interferon-gamma and antiviral beta chemokines. In persons with chronic infection, HIV-1-specific proliferative responses to p24 were inversely related to viral load. Strong HIV-1-specific proliferative responses were also detected following treatment of acutely infected persons with potent antiviral therapy. The HIV-1-specific helper cells are likely to be important in immunotherapeutic interventions and vaccine development.